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Prevalence of APOL1 Risk Variants in Afro-Descendant Patients with Chronic Kidney Disease in a Latin American Country
المؤلفون المشاركون
Duran, Carlos E.
Ramírez, Alejandro
Posada, Juan G.
Schweineberg, Johanna
Mesa, Liliana
Pachajoa, Harry
Estacio, Mayra
Manzi, Eliana
Aros, Vanessa
Díaz, Lorena
Garcia, Victor H.
المصدر
International Journal of Nephrology
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-18
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Introduction.
In Colombia, the genetic background of the populations was shaped by different levels of admixture between Natives, European, and Africans.
Approximately 35.363 patients have diagnosed chronic kidney disease and according to population studies, 10.4% of these patients are Afro-descendant.
We aim to assess the frequency of APOL1 variants G1 and G2 in Afro-descendant patients with ESRD treated at la Fundacion Valle del Lili University Hospital in Cali, Colombia.
Methods.
This is an observational cross-sectional study.
Afro-descendant patients with ESRD in waitlist or recipients of kidney transplant were evaluated.
Clinical data were collected from the electronic medical records.
Genotyping was carried out by amplification of the exon 7 of the APOL1 gene.
For the identification of risk genotypes, the bioinformatics tool BLAST was used.
Results.
We enrolled 102 participants.
The frequency of APOL1 risk variants was 67.2%, in which 24.5% (n = 25) were G1 heterozygous and 5.8% (n = 6) were G2 heterozygous and 37% of the patients had high-risk status with two alleles in homozygous (G1/G1 = 21 and G2/G2 = 3) or compound heterozygote (G1/G2 = 14) form.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Duran, Carlos E.& Ramírez, Alejandro& Posada, Juan G.& Schweineberg, Johanna& Mesa, Liliana& Pachajoa, Harry…[et al.]. 2019. Prevalence of APOL1 Risk Variants in Afro-Descendant Patients with Chronic Kidney Disease in a Latin American Country. International Journal of Nephrology،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1166508
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Duran, Carlos E.…[et al.]. Prevalence of APOL1 Risk Variants in Afro-Descendant Patients with Chronic Kidney Disease in a Latin American Country. International Journal of Nephrology No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1166508
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Duran, Carlos E.& Ramírez, Alejandro& Posada, Juan G.& Schweineberg, Johanna& Mesa, Liliana& Pachajoa, Harry…[et al.]. Prevalence of APOL1 Risk Variants in Afro-Descendant Patients with Chronic Kidney Disease in a Latin American Country. International Journal of Nephrology. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1166508
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1166508
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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