TSH Variability of Patients Affected by Differentiated Thyroid Cancer Treated with Levothyroxine Liquid Solution or Tablet Form
المؤلفون المشاركون
Morassi, M. L.
Casella, Claudio
Cappelli, Carlo
Pirola, Ilenia
Gandossi, Elena
Castellano, Maurizio
Marini, Fiorella
Lombardi, Davide
Delbarba, Andrea
المصدر
International Journal of Endocrinology
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-09
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Recent guidelines from the American Thyroid Association (ATA) indicate that, in many patients affected by differentiated thyroid cancer (DTC), the serum TSH should be maintained between 0.1 and 0.5 mU/L.
The purpose of this study was to evaluate the TSH variability of patients affected by DTC treated with liquid L-T4 formulation or in tablet form.
Patients and Methods.
Patients were eligible if (a) they were submitted to a total thyroidectomy and 131I remnant ablation for DTC in our institution and (b) they were classified low-risk patients according to ATA guidelines 2009.
Patients were randomized (1 : 1) to receive treatment of hypothyroidism with liquid L-T4 or tablet form.
The first check-up evaluation was made from 8 to 12 months after 131I remnant ablation.
TSH values were established again after further 12 months.
Results.
A significant increase in TSH values (median) was observed in patients taking tablets [TSH (min–max): 0.28 (0.1–0.45) versus 0.34 (0.01–0.78) mIU/L, p=0.041] as compared to those taking liquid formulation [TSH (min–max): 0.28 (0.1–0.47) versus 0.30 (0.1–0.55) mIU/L, p=0.345].
Conclusions.
The use of L-T4 liquid formulation, as compared to that of tablets, resulted in a significantly higher number of DTC patients maintaining TSH values in range for the ATA risk score, reducing TSH variability over the time.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cappelli, Carlo& Pirola, Ilenia& Gandossi, Elena& Casella, Claudio& Lombardi, Davide& Morassi, M. L.…[et al.]. 2017. TSH Variability of Patients Affected by Differentiated Thyroid Cancer Treated with Levothyroxine Liquid Solution or Tablet Form. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1166535
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cappelli, Carlo…[et al.]. TSH Variability of Patients Affected by Differentiated Thyroid Cancer Treated with Levothyroxine Liquid Solution or Tablet Form. International Journal of Endocrinology No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1166535
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cappelli, Carlo& Pirola, Ilenia& Gandossi, Elena& Casella, Claudio& Lombardi, Davide& Morassi, M. L.…[et al.]. TSH Variability of Patients Affected by Differentiated Thyroid Cancer Treated with Levothyroxine Liquid Solution or Tablet Form. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1166535
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1166535
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر