Oil Palm Phenolics Inhibit the In Vitro Aggregation of β-Amyloid Peptide into Oligomeric Complexes
المؤلفون المشاركون
Weinberg, Robert P.
Koledova, Vera V.
Shin, Hyeari
Park, Jennifer H.
Tan, Yew Ai
Sinskey, Anthony J.
Sambanthamurthi, Ravigadevi
Rha, ChoKyun
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-31
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Alzheimer’s disease is a severe neurodegenerative disease characterized by the aggregation of amyloid-β peptide (Aβ) into toxic oligomers which activate microglia and astrocytes causing acute neuroinflammation.
Multiple studies show that the soluble oligomers of Aβ42 are neurotoxic and proinflammatory, whereas the monomers and insoluble fibrils are relatively nontoxic.
We show that Aβ42 aggregation is inhibited in vitro by oil palm phenolics (OPP), an aqueous extract from the oil palm tree (Elaeis guineensis).
The data shows that OPP inhibits stacking of β-pleated sheets, which is essential for oligomerization.
We demonstrate the inhibition of Aβ42 aggregation by (1) mass spectrometry; (2) Congo Red dye binding; (3) 2D-IR spectroscopy; (4) dynamic light scattering; (5) transmission electron microscopy; and (6) transgenic yeast rescue assay.
In the yeast rescue assay, OPP significantly reduces the cytotoxicity of aggregating neuropeptides in yeast genetically engineered to overexpress these peptides.
The data shows that OPP inhibits (1) the aggregation of Aβ into oligomers; (2) stacking of β-pleated sheets; and (3) fibrillar growth and coalescence.
These inhibitory effects prevent the formation of neurotoxic oligomers and hold potential as a means to reduce neuroinflammation and neuronal death and thereby may play some role in the prevention or treatment of Alzheimer’s disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Weinberg, Robert P.& Koledova, Vera V.& Shin, Hyeari& Park, Jennifer H.& Tan, Yew Ai& Sinskey, Anthony J.…[et al.]. 2018. Oil Palm Phenolics Inhibit the In Vitro Aggregation of β-Amyloid Peptide into Oligomeric Complexes. International Journal of Alzheimer's Disease،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1166587
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Weinberg, Robert P.…[et al.]. Oil Palm Phenolics Inhibit the In Vitro Aggregation of β-Amyloid Peptide into Oligomeric Complexes. International Journal of Alzheimer's Disease No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1166587
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Weinberg, Robert P.& Koledova, Vera V.& Shin, Hyeari& Park, Jennifer H.& Tan, Yew Ai& Sinskey, Anthony J.…[et al.]. Oil Palm Phenolics Inhibit the In Vitro Aggregation of β-Amyloid Peptide into Oligomeric Complexes. International Journal of Alzheimer's Disease. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1166587
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1166587
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر