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Cholesterol Synthesis Increased in the MMI-Induced Subclinical Hypothyroidism Mice Model
المؤلفون المشاركون
Gao, Ling
Song, Yongfeng
Zhang, Xiujuan
Chen, Wenbin
المصدر
International Journal of Endocrinology
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-12
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Subclinical hypothyroidism (SCH) is defined as increased serum thyroid-stimulating hormone (TSH) concentrations and normal serum thyroid hormone (TH) levels as well as an increased serum cholesterol level, which is an important cause of secondary hypercholesterolemia and cardiovascular diseases.
Some studies have demonstrated a direct effect of TSH on cholesterol metabolism via in vivo and in vitro experiments.
However, because no suitable SCH model has been established until now, the changes in cholesterol synthesis that occur in SCH patients remain unknown.
Here, we establish an SCH mouse model by using long-term low-dose MMI administered in drinking water.
Compared with the control group, the MMI-treated mice had elevated circulating TSH levels, but the serum FT3 levels in these mice did not change.
Additionally, the TC levels increased in both the serum and liver of the experimental mice.
Both the protein expression and activity of hepatic HMGCR, the rate-limiting enzyme for cholesterol synthesis in the liver, increased in these mice.
We also found that the SCH mice had decreased phospho-HMGCR and phospho-AMPK expression, while the expression of AMPK showed no change.
In conclusion, we established a suitable SCH model in which cholesterol synthesis is increased.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Song, Yongfeng& Zhang, Xiujuan& Chen, Wenbin& Gao, Ling. 2017. Cholesterol Synthesis Increased in the MMI-Induced Subclinical Hypothyroidism Mice Model. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1166618
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Song, Yongfeng…[et al.]. Cholesterol Synthesis Increased in the MMI-Induced Subclinical Hypothyroidism Mice Model. International Journal of Endocrinology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1166618
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Song, Yongfeng& Zhang, Xiujuan& Chen, Wenbin& Gao, Ling. Cholesterol Synthesis Increased in the MMI-Induced Subclinical Hypothyroidism Mice Model. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1166618
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1166618
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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