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Evidence Supporting the Hypothesis That Inflammation-Induced Vasospasm Is Involved in the Pathogenesis of Acquired Sensorineural Hearing Loss
المؤلف
المصدر
International Journal of Otolaryngology
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-06
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Sensorineural hearing loss is mainly acquired and affects an estimated 1.3 billion humans worldwide.
It is related to aging, noise, infection, ototoxic drugs, and genetic defects.
It is essential to identify reversible and preventable causes to be able to reduce the burden of this disease.
Inflammation is involved in most causes and leads to tissue injury through vasospasm-associated ischemia.
Vasospasm is reversible.
This review summarized evidence linking inflammation-induced vasospasm to several forms of acquired sensorineural hearing loss.
The link between vasospasm and sensorineural hearing loss is directly evident in subarachnoid haemorrhage, which involves the release of vasoconstriction-inducing cytokines like interleukin-1, endothelin-1, and tumour necrosis factor.
These proinflammatory cytokines can also be released in response to infection, autoimmune disease, and acute or chronically increased inflammation in the ageing organism as in presbyacusis or in noise-induced cochlear injury.
Evidence of vasospasm and hearing loss has also been discovered in bacterial meningitis and brain injury.
Resolution of inflammation-induced vasospasm has been associated with improvement of hearing in autoimmune diseases involving overproduction of interleukin-1 from inflammasomes.
There is mainly indirect evidence for vasospasm-associated sensorineural hearing loss in most forms of systemic or injury- or infection-induced local vascular inflammation.
This opens up avenues in prevention and treatment of vascular and systemic inflammation as well as vasospasm itself as a way to prevent and treat most forms of acquired sensorineural hearing loss.
Future research needs to investigate interventions antagonising vasospasm and vasospasm-inducing proinflammatory cytokines and their production in randomised controlled trials of prevention and treatment of acquired sensorineural hearing loss.
Prime candidates for interventions are hereby inflammasome inhibitors and vasospasm-reducing drugs like nitric oxide donors, rho-kinase inhibitors, and magnesium which have the potential to reduce sensorineural hearing loss in meningitis, exposure to noise, brain injury, arteriosclerosis, and advanced age-related and autoimmune disease-related inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Eisenhut, Michael. 2019. Evidence Supporting the Hypothesis That Inflammation-Induced Vasospasm Is Involved in the Pathogenesis of Acquired Sensorineural Hearing Loss. International Journal of Otolaryngology،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1166698
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Eisenhut, Michael. Evidence Supporting the Hypothesis That Inflammation-Induced Vasospasm Is Involved in the Pathogenesis of Acquired Sensorineural Hearing Loss. International Journal of Otolaryngology No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1166698
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Eisenhut, Michael. Evidence Supporting the Hypothesis That Inflammation-Induced Vasospasm Is Involved in the Pathogenesis of Acquired Sensorineural Hearing Loss. International Journal of Otolaryngology. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1166698
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1166698
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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