Rifaximin Improves Visceral Hyperalgesia via TRPV1 by Modulating Intestinal Flora in the Water Avoidance Stressed Rat
المؤلفون المشاركون
Yang, Chang-qing
Guo, Xiao-shu
Ji-Li, Xiao-shu
Wei, Zi-bai
Zhao, Li
Zhao, Gan-ting
Sheng, Shu-ting
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-20
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Rifaximin is effective in relieving pain symptoms with IBS patients, although the mechanisms were not clear.
The aims of the research were to investigate whether the visceral hyperalgesia was alleviated by rifaximin via TRPV1 channel in rats.
Methods.
Rats were subjected to water avoidance stress (WAS) and were pretreated with rifaximin by oral gavage.
The visceromotor response to colorectal distension was measured.
The changes of TRPV1 in peripheral and central neurons of rats were detected by immunofluorescence, western blot method, and RT-PCR.
Bacterial 16S ribosomal DNA in ileal contents was assessed using the Illumina MiSeq platform.
The effect of intestinal flora on TRPV1 channel was observed by fecal microbiota transplantation (FMT) methods.
Results.
Rifaximin could relieve the visceral hyperalgesia and reduce the TRPV1 expression of neurons and ileum mucosa in rats induced by WAS.
The reduced relative abundance of intestinal flora induced by WAS could be partly prevented by rifaximin.
The electromyographical activities and immunoreactivity of TRPV1 in rats could be changed after FMT.
Conclusions.
Rifaximin could improve visceral hyperalgesia via TRPV1 channels of peripheral and central neurons by modulating intestinal flora in rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Chang-qing& Guo, Xiao-shu& Ji-Li, Xiao-shu& Wei, Zi-bai& Zhao, Li& Zhao, Gan-ting…[et al.]. 2020. Rifaximin Improves Visceral Hyperalgesia via TRPV1 by Modulating Intestinal Flora in the Water Avoidance Stressed Rat. Gastroenterology Research and Practice،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1166800
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Chang-qing…[et al.]. Rifaximin Improves Visceral Hyperalgesia via TRPV1 by Modulating Intestinal Flora in the Water Avoidance Stressed Rat. Gastroenterology Research and Practice No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1166800
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Chang-qing& Guo, Xiao-shu& Ji-Li, Xiao-shu& Wei, Zi-bai& Zhao, Li& Zhao, Gan-ting…[et al.]. Rifaximin Improves Visceral Hyperalgesia via TRPV1 by Modulating Intestinal Flora in the Water Avoidance Stressed Rat. Gastroenterology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1166800
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1166800
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر