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Pharmacokinetic and Pharmacodynamics of Sodium Diclofenac (Topical and IM) Associated with Laser Photobiomodulation on Skeletal Muscle Strain in Rats
المؤلفون المشاركون
de Paiva Carvalho, Rodrigo Leal
Leonardo, P. S. L. M.
Mendes, Gustavo Duarte
Lima, Fernanda Púpio Silva
Lima, Mário Oliveira
Marcos, Rodrigo Labat
Lopes-Martins, Rodrigo Alvaro Brandão
المصدر
International Journal of Photoenergy
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-03
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Purpose.
The practice of physical activities is considered a primary factor for the maintenance of good health status.
However, exhaustive or unusual physical activities can lead to muscle injuries.
Several treatments are used to recover muscle injuries; however, systemic NSAIDs often result in serious adverse events.
In this study, we aimed to investigate the association of laser therapy (LLLT) and topical diclofenac, evaluating the kinetics of the drug and its pharmacodynamic effect in stretching-induced muscle injury in rats.
Methods.
Male Wistar rats weighing 200 g were randomized and divided into groups of 6 animals.
Plasma concentrations of diclofenac were quantified by mass spectrometry at different times (15 min to 24 hours) in all animals.
The laser energy used was 3 Joules (830 nm; 100 mW, 30s).
Treated groups received diclofenac at the dose of 1 mg/kg IM or topically applied with or without laser therapy.
The electric stimulation was used to study the functional status of the muscles.
Results.
After topical administration of diclofenac, the peak plasma concentration (t max) occurred for 30 minutes in the irradiated group and 4 hours in the nonirradiated group.
The AUC (0-24 hs) was 442 (ng/h/mL-1) in the nonirradiated group and 712 (ng/h/mL-1) in the irradiated group.
Conclusion.
LLLT was effective to provide a significant improvement in functional patterns.
Taken together, our results demonstrate the synergistic effect between LLLT and topical diclofenac in muscle injury induced by stretching in rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de Paiva Carvalho, Rodrigo Leal& Leonardo, P. S. L. M.& Mendes, Gustavo Duarte& Lima, Fernanda Púpio Silva& Lima, Mário Oliveira& Marcos, Rodrigo Labat…[et al.]. 2019. Pharmacokinetic and Pharmacodynamics of Sodium Diclofenac (Topical and IM) Associated with Laser Photobiomodulation on Skeletal Muscle Strain in Rats. International Journal of Photoenergy،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1166957
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de Paiva Carvalho, Rodrigo Leal…[et al.]. Pharmacokinetic and Pharmacodynamics of Sodium Diclofenac (Topical and IM) Associated with Laser Photobiomodulation on Skeletal Muscle Strain in Rats. International Journal of Photoenergy No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1166957
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de Paiva Carvalho, Rodrigo Leal& Leonardo, P. S. L. M.& Mendes, Gustavo Duarte& Lima, Fernanda Púpio Silva& Lima, Mário Oliveira& Marcos, Rodrigo Labat…[et al.]. Pharmacokinetic and Pharmacodynamics of Sodium Diclofenac (Topical and IM) Associated with Laser Photobiomodulation on Skeletal Muscle Strain in Rats. International Journal of Photoenergy. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1166957
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1166957
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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