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Identifying Novel Glioma-Associated Noncoding RNAs by Their Expression Profiles
المؤلفون المشاركون
Boštjančič, Emanuela
Glavač, Damjan
Matjašič, Alenka
Tajnik, Mojca
Popović, Mara
Matos, Boštjan
المصدر
International Journal of Genomics
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-12
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) play a significant role in cancer development as regulators of protein-coding genes.
Their dysregulation was in some extent already associated with glioma, the most aggressive primary brain tumours in adults.
The correct diagnosis and treatment selection due to high tumour heterogeneity might be difficult and inadequate, resulting in poor prognosis.
Studies of expression patterns of noncoding RNAs (ncRNAs) could provide useful insight in glioma molecular development.
We used the qPCR approach to screen and investigate the expression of lncRNAs that were previously deregulated in other cancer types.
The study showed altered expression levels for numerous lncRNAs across histologically different glioma samples.
Validation of few lncRNAs showed association of expression levels with histological subtype and/or malignancy grade.
We also observed deregulated and subtype-distinctive expression for four lncRNA-associated miRNAs.
Expression of few lncRNAs and miRNA was also associated with patients’ survival, showing potential prognostic value.
Several ncRNAs, some already related to glioma and some, to the best of our knowledge, investigated for the first time, might be of greater importance in glioma molecular development and progression.
Finding the subtype-specific lncRNA and/or miRNA expression patterns may contribute additional information for a more objective classification.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Matjašič, Alenka& Tajnik, Mojca& Boštjančič, Emanuela& Popović, Mara& Matos, Boštjan& Glavač, Damjan. 2017. Identifying Novel Glioma-Associated Noncoding RNAs by Their Expression Profiles. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1166999
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Matjašič, Alenka…[et al.]. Identifying Novel Glioma-Associated Noncoding RNAs by Their Expression Profiles. International Journal of Genomics No. 2017 (2017), pp.1-18.
https://search.emarefa.net/detail/BIM-1166999
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Matjašič, Alenka& Tajnik, Mojca& Boštjančič, Emanuela& Popović, Mara& Matos, Boštjan& Glavač, Damjan. Identifying Novel Glioma-Associated Noncoding RNAs by Their Expression Profiles. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1166999
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1166999
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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