Evidence of Divergent Amino Acid Usage in Comparative Analyses of R5- and X4-Associated HIV-1 Vpr Sequences
المؤلفون المشاركون
Nonnemacher, Michael R.
Pirrone, Vanessa
Wigdahl, Brian
Antell, Gregory C.
Dampier, Will
Zhong, Wen
Kercher, Katherine
Passic, Shendra
Williams, Jean
Liu, Yucheng
James, Tony
Jacobson, Jeffrey M.
Szep, Zsofia
Aiamkitsumrit, Benjamas
Krebs, Fred C.
المصدر
International Journal of Genomics
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-23
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Vpr is an HIV-1 accessory protein that plays numerous roles during viral replication, and some of which are cell type dependent.
To test the hypothesis that HIV-1 tropism extends beyond the envelope into the vpr gene, studies were performed to identify the associations between coreceptor usage and Vpr variation in HIV-1-infected patients.
Colinear HIV-1 Env-V3 and Vpr amino acid sequences were obtained from the LANL HIV-1 sequence database and from well-suppressed patients in the Drexel/Temple Medicine CNS AIDS Research and Eradication Study (CARES) Cohort.
Genotypic classification of Env-V3 sequences as X4 (CXCR4-utilizing) or R5 (CCR5-utilizing) was used to group colinear Vpr sequences.
To reveal the sequences associated with a specific coreceptor usage genotype, Vpr amino acid sequences were assessed for amino acid diversity and Jensen-Shannon divergence between the two groups.
Five amino acid alphabets were used to comprehensively examine the impact of amino acid substitutions involving side chains with similar physiochemical properties.
Positions 36, 37, 41, 89, and 96 of Vpr were characterized by statistically significant divergence across multiple alphabets when X4 and R5 sequence groups were compared.
In addition, consensus amino acid switches were found at positions 37 and 41 in comparisons of the R5 and X4 sequence populations.
These results suggest an evolutionary link between Vpr and gp120 in HIV-1-infected patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Antell, Gregory C.& Dampier, Will& Aiamkitsumrit, Benjamas& Nonnemacher, Michael R.& Pirrone, Vanessa& Zhong, Wen…[et al.]. 2017. Evidence of Divergent Amino Acid Usage in Comparative Analyses of R5- and X4-Associated HIV-1 Vpr Sequences. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1167054
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Antell, Gregory C.…[et al.]. Evidence of Divergent Amino Acid Usage in Comparative Analyses of R5- and X4-Associated HIV-1 Vpr Sequences. International Journal of Genomics No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1167054
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Antell, Gregory C.& Dampier, Will& Aiamkitsumrit, Benjamas& Nonnemacher, Michael R.& Pirrone, Vanessa& Zhong, Wen…[et al.]. Evidence of Divergent Amino Acid Usage in Comparative Analyses of R5- and X4-Associated HIV-1 Vpr Sequences. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1167054
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1167054
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر