Prognostic and Diagnostic Significance of circRNA Expression in Esophageal Cancer: A Meta-analysis
المؤلفون المشاركون
Lin, Hong
Yuan, Jinpeng
Liang, Guoxi
Wu, Yanxuan
Chen, Liming
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-01
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background and Aims.
Circular RNA (circRNA) demonstrates potential biological application in various solid tumors.
We intended to evaluate the diagnostic, prognostic, and clinicopathological value of circRNA for esophageal cancer (EC).
Methods.
We screened relative studies from Pubmed, Embase, Web of Science, and Cochrane Library.
The diagnostic role of circRNAs was testified by pooled sensitivity and specificity.
Pooled odds ratio (OR) and pooled hazard ratio (HR) were computed to appraise the clinicopathological and prognostic value, respectively.
Results.
There were total 15 articles suitable with our included criteria, in which 7 for diagnosis, 8 for prognosis, and 9 for clinicopathological features.
The pooled sensitivity and specificity were 0.77 and 0.80, respectively, while the AUC was 0.85.
Patients with aberrant expression of circRNAs had a 2.92-fold increased risk of developing EC.
The proportion of EC patients with normal circRNA expression only accounted for 29%.
Upregulated expression of oncogenic circRNA was correlated with poor clinicopathological features, including lymph node metastasis, tumor size, and T classification, while downregulation of tumor-suppressor circRNA was contributed to worse TNM stage.
As for prognosis, upregulated expression of circRNA carried out a diverse survival outcome, with a pooled HR of 2.76 for tumor promoter and that of 0.21 for tumor suppressor.
High expression of oncogenic circRNA in both plasma and tumor tissue would lead to a shorter survival duration.
Conclusion.
circRNAs might be a promising biomarker for diagnosis, prognosis, and clinicopathological features of EC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Hong& Yuan, Jinpeng& Liang, Guoxi& Wu, Yanxuan& Chen, Liming. 2020. Prognostic and Diagnostic Significance of circRNA Expression in Esophageal Cancer: A Meta-analysis. Gastroenterology Research and Practice،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1167055
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Hong…[et al.]. Prognostic and Diagnostic Significance of circRNA Expression in Esophageal Cancer: A Meta-analysis. Gastroenterology Research and Practice No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1167055
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Hong& Yuan, Jinpeng& Liang, Guoxi& Wu, Yanxuan& Chen, Liming. Prognostic and Diagnostic Significance of circRNA Expression in Esophageal Cancer: A Meta-analysis. Gastroenterology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1167055
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1167055
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر