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Vitamin D Receptor Gene Polymorphisms Influence T1D Susceptibility among Pakistanis
المؤلفون المشاركون
Mukhtar, Maryam
Batool, Andleeb
Wajid, Abdul
Qayyum, Iram
المصدر
International Journal of Genomics
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-03
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
The vitamin D receptor (VDR) gene regulates insulin secretion from the pancreas and acts as a mediator of the immune response through vitamin D.
Polymorphism in VDR causes alterations in the functioning of vitamin D, leading to type 1 diabetes (T1D) predisposition.
The aim of the present study was to determine VDR gene polymorphism in association with T1D in Pakistanis.
Methods.
The association was evaluated by selecting rs2228570 (FokΙ), rs7975232 (ApaΙ), and rs731236 (TaqΙ) polymorphic sites in 102 patients and 100 controls.
Genotypes were identified by DNA sequencing and PCR-RFLP.
Results.
The allelic and genotypic frequencies of FokΙ and ApaI were significantly associated with T1D (p<0.001) development.
At the FokΙ site, tryptophan was replaced with arginine due to polymorphism.
A novel SNP (GeneBank acc number KT280406) was identified through the sequencing of intron 8, 62 bp downstream from the ApaI polymorphic site, and significantly associated with T1D development.
The TaqΙ did not depict any association with T1D at the allelic or genotypic level (p>0.05).
CCGC, CCGG, CCTC, and CCTG haplotypes were significantly associated with disease development (p<0.05).
However, CTGG haplotype was protective towards T1D (p<0.01).
Conclusion.
VDR polymorphisms were identified as susceptible regions for T1D development in the Pakistani population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mukhtar, Maryam& Batool, Andleeb& Wajid, Abdul& Qayyum, Iram. 2017. Vitamin D Receptor Gene Polymorphisms Influence T1D Susceptibility among Pakistanis. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1167058
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mukhtar, Maryam…[et al.]. Vitamin D Receptor Gene Polymorphisms Influence T1D Susceptibility among Pakistanis. International Journal of Genomics No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1167058
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mukhtar, Maryam& Batool, Andleeb& Wajid, Abdul& Qayyum, Iram. Vitamin D Receptor Gene Polymorphisms Influence T1D Susceptibility among Pakistanis. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1167058
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1167058
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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