An Indole Alkaloid Extracted from Evodia rutaecarpa Inhibits Colonic Motility of Rats In Vitro
المؤلفون المشاركون
Wang, Guo-xiang
Xiang, Yan-li
Wang, Hong-gang
Miu, Yang-de
Yu, Guang
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-03
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Evodiamine (Evo) is an indole alkaloid extracted from the traditional Chinese medicinal herb Evodia rutaecarpa.
Evo may regulate gastrointestinal motility, but the evidence is insufficient, and the mechanisms remain unknown.
The aim of this study was to investigate the effect of Evo on colonic motility of rats and the underlying mechanisms in vitro.
Rat colonic muscle was exposed to Evo (10 and 100 μM) followed by immunohistochemistry of cholecystokinin receptor 1 (CCK1R).
Muscle contractions were studied in an organ bath system to determine whether CCK1R, nitric oxide (NO), and enteric neurons are involved in the relaxant effect of Evo.
Whole-cell patch-clamp was used to detect L-type calcium currents (ICa,L) in isolated colonic smooth muscle cells (SMCs).
CCK1R was observed in SMCs, intermuscular neurons, and mucosa of rat colon.
Evo could inhibit spontaneous muscle contractions; NO synthase, inhibitor L-NAME CCK1R antagonist, could partly block this effect, while the enteric neurons may not play a major role.
Evo inhibited the peak ICa,L in colonic SMCs at a membrane potential of 0 mV.
The current-voltage (I–V) relationship of L-type calcium channels was modified by Evo, while the peak of the I–V curve remained at 0 mV.
Furthermore, Evo inhibited the activation of L-type calcium channels and decreased the peak ICa,L.
The relaxant effect of Evo on colonic muscle is associated with the inhibition of L-type calcium channels.
The enteric neurons, NO, and CCK1R may be partly related to the inhibitory effect of Evo on colonic motility.
This study provides the first evidence that evodiamine can regulate colonic motility in rats by mediating calcium homeostasis in smooth muscle cells.
These data form a theoretical basis for the clinical application of evodiamine for treatment of gastrointestinal motility diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Guo-xiang& Xiang, Yan-li& Wang, Hong-gang& Miu, Yang-de& Yu, Guang. 2020. An Indole Alkaloid Extracted from Evodia rutaecarpa Inhibits Colonic Motility of Rats In Vitro. Gastroenterology Research and Practice،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1167064
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Guo-xiang…[et al.]. An Indole Alkaloid Extracted from Evodia rutaecarpa Inhibits Colonic Motility of Rats In Vitro. Gastroenterology Research and Practice No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1167064
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Guo-xiang& Xiang, Yan-li& Wang, Hong-gang& Miu, Yang-de& Yu, Guang. An Indole Alkaloid Extracted from Evodia rutaecarpa Inhibits Colonic Motility of Rats In Vitro. Gastroenterology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1167064
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1167064
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر