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Serum and Brain Metabolomic Variations Reveal Perturbation of Sleep Deprivation on Rats and Ameliorate Effect of Total Ginsenoside Treatment
المؤلفون المشاركون
Zhou, Mingmei
Xu, Ying
Cen, Fang
Fan, Zi-quan
Shen, Hong-yi
Gou, Xiao-jun
المصدر
International Journal of Genomics
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-16
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Sleep loss or sleep deprivation (SD) refers to shorter sleep than average baseline need, and SD has been a serious problem of modern societies which affects health and well-being.
Panax ginseng is a well-known traditional Chinese medicine (TCM).
Our previous study has demonstrated that total ginsenosides (GS), the extracts from Panax ginseng, could effectively improve cognition and behavior on SD rats.
However, little is known about its metabolomic study.
In this study, serum and brain metabolomic method based on gas chromatography coupled with mass spectrometry (GC/MS) was employed to evaluate the efficacy and study the mechanism of GS on a rat model of SD.
With pattern recognition analysis of serum and brain tissue metabolite profile, a clear separation of the model group and control group was acquired for serum and brain tissue samples; the MGS (model + GS) group showed a tendency of recovering when compared to control group, which was consistent with behavioral and biochemical parameters.
39 and 40 potential biomarkers of brain tissues and serum samples, respectively, were identified and employed to explore the possible mechanism.
Our work revealed that GS has significant protective effects on SD, and metabolomics is a useful tool for evaluating efficacy and elucidating mechanism in TCM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gou, Xiao-jun& Cen, Fang& Fan, Zi-quan& Xu, Ying& Shen, Hong-yi& Zhou, Mingmei. 2017. Serum and Brain Metabolomic Variations Reveal Perturbation of Sleep Deprivation on Rats and Ameliorate Effect of Total Ginsenoside Treatment. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1167104
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gou, Xiao-jun…[et al.]. Serum and Brain Metabolomic Variations Reveal Perturbation of Sleep Deprivation on Rats and Ameliorate Effect of Total Ginsenoside Treatment. International Journal of Genomics No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1167104
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gou, Xiao-jun& Cen, Fang& Fan, Zi-quan& Xu, Ying& Shen, Hong-yi& Zhou, Mingmei. Serum and Brain Metabolomic Variations Reveal Perturbation of Sleep Deprivation on Rats and Ameliorate Effect of Total Ginsenoside Treatment. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1167104
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1167104
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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