The Numerical Predominance and Large Transcriptome Differences of Neutrophils in Peripheral Blood Together Inevitably Account for a Reported Pulmonary Tuberculosis Signature
المؤلفون المشاركون
Lowrie, Douglas B.
Wong, Ka-Wing
Fan, Xiao-Yong
Wu, Kang
Deng, Wang-Long
Zhang, Hao
Li, Jing
المصدر
International Journal of Genomics
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-06
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Previous transcriptomic analysis revealed a 393-transcript signature (PTBsig), which is dominated by interferon inducible genes, in whole blood of pulmonary tuberculosis (PTB) patients.
Comparisons with a limited set of interferon-driven genes among separated monocytes, CD4+ T cells, CD8+ T cells, and neutrophils indicated that the signature is due to changes in neutrophils, the overwhelmingly predominant cell type.
By extending the analysis to the entire 393 transcripts of PTBsig and by switching the cell proportions between separated monocytes, CD4+ T cells, CD8+ T cells, and neutrophils, we create putative PTBsig for whole blood (pPTBsig) in which CD4+ or CD8+ T cells or monocytes predominated or in which the cell proportions were unchanged.
These putative signatures are then compared to the actual reported PTBsig.
We show that, because of their predominance in peripheral blood and their larger transcriptional responses, neutrophils were indeed almost exclusively responsible for PTBsig.
We caution that the functional significance of changes in other cell types might escape notice in transcriptome analysis that is based upon whole blood.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Kang& Wong, Ka-Wing& Deng, Wang-Long& Zhang, Hao& Li, Jing& Lowrie, Douglas B.…[et al.]. 2017. The Numerical Predominance and Large Transcriptome Differences of Neutrophils in Peripheral Blood Together Inevitably Account for a Reported Pulmonary Tuberculosis Signature. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1167138
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Kang…[et al.]. The Numerical Predominance and Large Transcriptome Differences of Neutrophils in Peripheral Blood Together Inevitably Account for a Reported Pulmonary Tuberculosis Signature. International Journal of Genomics No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1167138
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Kang& Wong, Ka-Wing& Deng, Wang-Long& Zhang, Hao& Li, Jing& Lowrie, Douglas B.…[et al.]. The Numerical Predominance and Large Transcriptome Differences of Neutrophils in Peripheral Blood Together Inevitably Account for a Reported Pulmonary Tuberculosis Signature. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1167138
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1167138
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر