Biological Function of MicroRNA193a-3p in Health and Disease
المؤلفون المشاركون
Grossi, Ilaria
Salvi, Alessandro
Abeni, Edoardo
Marchina, Eleonora
De Petro, Giuseppina
المصدر
International Journal of Genomics
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-05
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
MicroRNAs (miRNAs) are a class of small noncoding RNAs that act mainly as negative regulators of gene expression.
Several studies demonstrated that miRNAs take part in numerous biological processes, such as proliferation, apoptosis, and migration.
The dysregulation of miRNAs has been frequently observed in different types of disease, including cancer.
Here, we provide a comprehensive review on the human miR-193a-3p by considering its role in both physiological and pathological contexts.
Different mechanisms involved in regulating miR-193a-3p expression have been reported, including epigenetic modifications and transcription factors.
In physiological contexts, miR-193a-3p seemed able to limit proliferation and cell cycle progression in normal cells.
Remarkably, several publications demonstrated that miR-193a-3p acted as a tumor suppressor miRNA in cancer by targeting different genes involved in proliferation, apoptosis, migration, invasion, and metastasis.
Furthermore, the downregulation of miR-193a-3p has been observed in many primary tumors and altered levels of circulating miR-193a-3p have been identified in serum or plasma of cancer patients and subjects affected by Parkinson’s disease or by schizophrenia.
In a clinical perspective, further studies are needed to explore the antitumor effects of the miR-193a-3p mimics delivery and the relevance of this miRNA detection as a possible diagnostic and prognostic biomarker.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Grossi, Ilaria& Salvi, Alessandro& Abeni, Edoardo& Marchina, Eleonora& De Petro, Giuseppina. 2017. Biological Function of MicroRNA193a-3p in Health and Disease. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1167152
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Grossi, Ilaria…[et al.]. Biological Function of MicroRNA193a-3p in Health and Disease. International Journal of Genomics No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1167152
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Grossi, Ilaria& Salvi, Alessandro& Abeni, Edoardo& Marchina, Eleonora& De Petro, Giuseppina. Biological Function of MicroRNA193a-3p in Health and Disease. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1167152
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1167152
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر