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Naturally Occurring Canine Invasive Urinary Bladder Cancer: A Complementary Animal Model to Improve the Success Rate in Human Clinical Trials of New Cancer Drugs
المؤلفون المشاركون
Fulkerson, Christopher M.
Dhawan, Deepika
Ratliff, Timothy L.
Hahn, Noah M.
Knapp, Deborah W.
المصدر
International Journal of Genomics
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-04-09
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Genomic analyses are defining numerous new targets for cancer therapy.
Therapies aimed at specific genetic and epigenetic targets in cancer cells as well as expanded development of immunotherapies are placing increased demands on animal models.
Traditional experimental models do not possess the collective features (cancer heterogeneity, molecular complexity, invasion, metastasis, and immune cell response) critical to predict success or failure of emerging therapies in humans.
There is growing evidence, however, that dogs with specific forms of naturally occurring cancer can serve as highly relevant animal models to complement traditional models.
Invasive urinary bladder cancer (invasive urothelial carcinoma (InvUC)) in dogs, for example, closely mimics the cancer in humans in pathology, molecular features, biological behavior including sites and frequency of distant metastasis, and response to chemotherapy.
Genomic analyses are defining further intriguing similarities between InvUC in dogs and that in humans.
Multiple canine clinical trials have been completed, and others are in progress with the aim of translating important findings into humans to increase the success rate of human trials, as well as helping pet dogs.
Examples of successful targeted therapy studies and the challenges to be met to fully utilize naturally occurring dog models of cancer will be reviewed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fulkerson, Christopher M.& Dhawan, Deepika& Ratliff, Timothy L.& Hahn, Noah M.& Knapp, Deborah W.. 2017. Naturally Occurring Canine Invasive Urinary Bladder Cancer: A Complementary Animal Model to Improve the Success Rate in Human Clinical Trials of New Cancer Drugs. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1167199
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fulkerson, Christopher M.…[et al.]. Naturally Occurring Canine Invasive Urinary Bladder Cancer: A Complementary Animal Model to Improve the Success Rate in Human Clinical Trials of New Cancer Drugs. International Journal of Genomics No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1167199
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fulkerson, Christopher M.& Dhawan, Deepika& Ratliff, Timothy L.& Hahn, Noah M.& Knapp, Deborah W.. Naturally Occurring Canine Invasive Urinary Bladder Cancer: A Complementary Animal Model to Improve the Success Rate in Human Clinical Trials of New Cancer Drugs. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1167199
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1167199
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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