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Transcriptome-Based Modeling Reveals that Oxidative Stress Induces Modulation of the AtfA-Dependent Signaling Networks in Aspergillus nidulans
المؤلفون المشاركون
Pócsi, István
Orosz, Erzsébet
Antal, Károly
Gazdag, Zoltán
Szabó, Zsuzsa
Han, Kap-Hoon
Yu, Jae-Hyuk
Emri, Tamás
المصدر
International Journal of Genomics
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-09
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
To better understand the molecular functions of the master stress-response regulator AtfA in Aspergillus nidulans, transcriptomic analyses of the atfA null mutant and the appropriate control strains exposed to menadione sodium bisulfite- (MSB-), t-butylhydroperoxide- and diamide-induced oxidative stresses were performed.
Several elements of oxidative stress response were differentially expressed.
Many of them, including the downregulation of the mitotic cell cycle, as the MSB stress-specific upregulation of FeS cluster assembly and the MSB stress-specific downregulation of nitrate reduction, tricarboxylic acid cycle, and ER to Golgi vesicle-mediated transport, showed AtfA dependence.
To elucidate the potential global regulatory role of AtfA governing expression of a high number of genes with very versatile biological functions, we devised a model based on the comprehensive transcriptomic data.
Our model suggests that an important function of AtfA is to modulate the transduction of stress signals.
Although it may regulate directly only a limited number of genes, these include elements of the signaling network, for example, members of the two-component signal transduction systems.
AtfA acts in a stress-specific manner, which may increase further the number and diversity of AtfA-dependent genes.
Our model sheds light on the versatility of the physiological functions of AtfA and its orthologs in fungi.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Orosz, Erzsébet& Antal, Károly& Gazdag, Zoltán& Szabó, Zsuzsa& Han, Kap-Hoon& Yu, Jae-Hyuk…[et al.]. 2017. Transcriptome-Based Modeling Reveals that Oxidative Stress Induces Modulation of the AtfA-Dependent Signaling Networks in Aspergillus nidulans. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1167211
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Orosz, Erzsébet…[et al.]. Transcriptome-Based Modeling Reveals that Oxidative Stress Induces Modulation of the AtfA-Dependent Signaling Networks in Aspergillus nidulans. International Journal of Genomics No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1167211
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Orosz, Erzsébet& Antal, Károly& Gazdag, Zoltán& Szabó, Zsuzsa& Han, Kap-Hoon& Yu, Jae-Hyuk…[et al.]. Transcriptome-Based Modeling Reveals that Oxidative Stress Induces Modulation of the AtfA-Dependent Signaling Networks in Aspergillus nidulans. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1167211
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1167211
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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