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An Exploration of Gene-Gene Interactions and Their Effects on Hypertension
المؤلفون المشاركون
Meng, Ying
Groth, Susan
Quinn, Jill R.
Bisognano, John
Wu, Tong Tong
المصدر
International Journal of Genomics
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-31
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Hypertension tends to perpetuate in families and the heritability of hypertension is estimated to be around 20–60%.
So far, the main proportion of this heritability has not been found by single-locus genome-wide association studies.
Therefore, the current study explored gene-gene interactions that have the potential to partially fill in the missing heritability.
A two-stage discovery-confirmatory analysis was carried out in the Framingham Heart Study cohorts.
The first stage was an exhaustive pairwise search performed in 2320 early-onset hypertensive cases with matched normotensive controls from the offspring cohort.
Then, identified gene-gene interactions were assessed in an independent set of 694 subjects from the original cohort.
Four unique gene-gene interactions were found to be related to hypertension.
Three detected genes were recognized by previous studies, and the other 5 loci/genes (MAN1A1, LMO3, NPAP1/SNRPN, DNAL4, and RNA5SP455/KRT8P5) were novel findings, which had no strong main effect on hypertension and could not be easily identified by single-locus genome-wide studies.
Also, by including the identified gene-gene interactions, more variance was explained in hypertension.
Overall, our study provides evidence that the genome-wide gene-gene interaction analysis has the possibility to identify new susceptibility genes, which can provide more insights into the genetic background of blood pressure regulation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Meng, Ying& Groth, Susan& Quinn, Jill R.& Bisognano, John& Wu, Tong Tong. 2017. An Exploration of Gene-Gene Interactions and Their Effects on Hypertension. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1167217
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Meng, Ying…[et al.]. An Exploration of Gene-Gene Interactions and Their Effects on Hypertension. International Journal of Genomics No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1167217
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Meng, Ying& Groth, Susan& Quinn, Jill R.& Bisognano, John& Wu, Tong Tong. An Exploration of Gene-Gene Interactions and Their Effects on Hypertension. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1167217
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1167217
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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