Exception to the Rule: Genomic Characterization of Naturally Occurring Unusual Vibrio cholerae Strains with a Single Chromosome
المؤلفون المشاركون
Detter, John C.
Davenport, Karen
Chain, Patrick
Xie, Gary
Johnson, Shannon L.
Rajavel, Mathumathi
Waldminghaus, Torsten
Sozhamannan, Shanmuga
المصدر
International Journal of Genomics
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-29
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The genetic make-up of most bacteria is encoded in a single chromosome while about 10% have more than one chromosome.
Among these, Vibrio cholerae, with two chromosomes, has served as a model system to study various aspects of chromosome maintenance, mainly replication, and faithful partitioning of multipartite genomes.
Here, we describe the genomic characterization of strains that are an exception to the two chromosome rules: naturally occurring single-chromosome V.
cholerae.
Whole genome sequence analyses of NSCV1 and NSCV2 (natural single-chromosome vibrio) revealed that the Chr1 and Chr2 fusion junctions contain prophages, IS elements, and direct repeats, in addition to large-scale chromosomal rearrangements such as inversions, insertions, and long tandem repeats elsewhere in the chromosome compared to prototypical two chromosome V.
cholerae genomes.
Many of the known cholera virulence factors are absent.
The two origins of replication and associated genes are generally intact with synonymous mutations in some genes, as are recA and mismatch repair (MMR) genes dam, mutH, and mutL; MutS function is probably impaired in NSCV2.
These strains are ideal tools for studying mechanistic aspects of maintenance of chromosomes with multiple origins and other rearrangements and the biological, functional, and evolutionary significance of multipartite genome architecture in general.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xie, Gary& Johnson, Shannon L.& Davenport, Karen& Rajavel, Mathumathi& Waldminghaus, Torsten& Detter, John C.…[et al.]. 2017. Exception to the Rule: Genomic Characterization of Naturally Occurring Unusual Vibrio cholerae Strains with a Single Chromosome. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1167254
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xie, Gary…[et al.]. Exception to the Rule: Genomic Characterization of Naturally Occurring Unusual Vibrio cholerae Strains with a Single Chromosome. International Journal of Genomics No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1167254
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xie, Gary& Johnson, Shannon L.& Davenport, Karen& Rajavel, Mathumathi& Waldminghaus, Torsten& Detter, John C.…[et al.]. Exception to the Rule: Genomic Characterization of Naturally Occurring Unusual Vibrio cholerae Strains with a Single Chromosome. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1167254
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1167254
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر