Azithromycin in the Treatment of Preterm Prelabor Rupture of Membranes Demonstrates a Lower Risk of Chorioamnionitis and Postpartum Endometritis with an Equivalent Latency Period Compared with Erythromycin Antibiotic Regimens
المؤلفون المشاركون
Martingano, Daniel
Singh, Shailini
Mitrofanova, Antonina
المصدر
Infectious Diseases in Obstetrics and Gynecology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-09
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
To determine if antibiotic regimens including azithromycin versus erythromycin has an impact on pregnancy latency and development of clinical chorioamnionitis in the context of preterm prelabor rupture of membranes.
Study Design.
We conducted a prospective observational cohort study and followed all women receiving antibiotic regimens including either azithromycin or erythromycin in the context of preterm prelabor rupture of membranes.
Primary outcomes were the duration of pregnancy latency period and development of chorioamnionitis.
Secondary outcomes included neonatal sepsis with positive blood culture, cesarean delivery, postpartum endometritis, and meconium-stained amniotic fluid.
Results.
This study included 310 patients, with 142 receiving the azithromycin regimen and 168 receiving the erythromycin regimen.
Patients receiving the azithromycin regimen had a statistically significant advantage in overall rates of clinical chorioamnionitis (13.4% versus 25%, p=0.010), neonatal sepsis (4.9% versus 14.9%, p=0.004), and postpartum endometritis (14.8% versus 31%, p=0.001).
In crude and adjusted models, when comparing the azithromycin group with the erythromycin group, a decreased risk was noted for the development of clinical chorioamnionitis, neonatal sepsis, and postpartum endometritis.
Pregnancy latency by regimen was not significantly different in crude and adjusted models.
Conclusion.
Our study suggests that latency antibiotic regimens substituting azithromycin for erythromycin have lower rates and decreased risk of clinical chorioamnionitis, neonatal sepsis, and postpartum endometritis with no difference in pregnancy latency.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Martingano, Daniel& Singh, Shailini& Mitrofanova, Antonina. 2020. Azithromycin in the Treatment of Preterm Prelabor Rupture of Membranes Demonstrates a Lower Risk of Chorioamnionitis and Postpartum Endometritis with an Equivalent Latency Period Compared with Erythromycin Antibiotic Regimens. Infectious Diseases in Obstetrics and Gynecology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1167258
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Martingano, Daniel…[et al.]. Azithromycin in the Treatment of Preterm Prelabor Rupture of Membranes Demonstrates a Lower Risk of Chorioamnionitis and Postpartum Endometritis with an Equivalent Latency Period Compared with Erythromycin Antibiotic Regimens. Infectious Diseases in Obstetrics and Gynecology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1167258
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Martingano, Daniel& Singh, Shailini& Mitrofanova, Antonina. Azithromycin in the Treatment of Preterm Prelabor Rupture of Membranes Demonstrates a Lower Risk of Chorioamnionitis and Postpartum Endometritis with an Equivalent Latency Period Compared with Erythromycin Antibiotic Regimens. Infectious Diseases in Obstetrics and Gynecology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1167258
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1167258
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر