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Association of PTPN22 Haplotypes (−1123G>C+1858C>T) with Rheumatoid Arthritis in Western Mexican Population
المؤلفون المشاركون
Padilla-Gutiérrez, Jorge Ramón
Valle, Yeminia
Muñoz-Valle, Jose F.
Hernández-Bello, Jorge
Ruiz-Noa, Yeniley
Palafox-Sánchez, Claudia Azucena
Oregón-Romero, Edith
Pereira-Suárez, Ana Laura
Bernard-Medina, Ana Guilaisne
المصدر
International Journal of Genomics
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-22
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Rheumatoid arthritis (RA) is an autoimmune disease characterized by the presence of antibodies against cyclic citrullinated peptide (anti-CCP), a consequence of the breakdown of immune tolerance.
The lymphoid tyrosine phosphatase (Lyp) protein has significant effects on maintenance of peripheral immune tolerance.
Two polymorphic variants (−1123G>C and +1858C>T) at PTPN22 gene that encodes this protein have been associated with autoimmune disorders and found in strong linkage disequilibrium in Caucasian population.
We evaluated whether PTPN22 haplotypes (−1123G>C/+1858C>T) are associated with anti-CCP antibodies, as well as susceptibility to RA in a Western Mexican population.
A total of 315 RA patients and 315 control subjects (CS) were included.
The polymorphisms were genotyped by PCR-RFLP and the anti-CCP antibodies were determined by ELISA.
The PTPN22 polymorphisms were in strong linkage disequilibrium (D′ = 1.00 in CS).
The susceptibility haplotype CT was significantly more frequent in RA patients than in CS (OR 2.18, 95% CI 1.15–4.16, p=0.01).
No association between haplotypes and anti-CCP antibodies levels was observed.
In conclusion, this study confirmed that −1123G>C and +1858C>T PTPN22 polymorphisms are in strong linkage disequilibrium and the CT haplotype is a susceptibility marker to RA in Western Mexico.
However, the PTPN22 haplotypes are not associated with anti-CCP antibodies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ruiz-Noa, Yeniley& Padilla-Gutiérrez, Jorge Ramón& Hernández-Bello, Jorge& Palafox-Sánchez, Claudia Azucena& Valle, Yeminia& Oregón-Romero, Edith…[et al.]. 2017. Association of PTPN22 Haplotypes (−1123G>C+1858C>T) with Rheumatoid Arthritis in Western Mexican Population. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1167262
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ruiz-Noa, Yeniley…[et al.]. Association of PTPN22 Haplotypes (−1123G>C+1858C>T) with Rheumatoid Arthritis in Western Mexican Population. International Journal of Genomics No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1167262
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ruiz-Noa, Yeniley& Padilla-Gutiérrez, Jorge Ramón& Hernández-Bello, Jorge& Palafox-Sánchez, Claudia Azucena& Valle, Yeminia& Oregón-Romero, Edith…[et al.]. Association of PTPN22 Haplotypes (−1123G>C+1858C>T) with Rheumatoid Arthritis in Western Mexican Population. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1167262
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1167262
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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