Association of PTPN22 Haplotypes (−1123G>C+1858C>T) with Rheumatoid Arthritis in Western Mexican Population
المؤلفون المشاركون
Padilla-Gutiérrez, Jorge Ramón
Valle, Yeminia
Muñoz-Valle, Jose F.
Hernández-Bello, Jorge
Ruiz-Noa, Yeniley
Palafox-Sánchez, Claudia Azucena
Oregón-Romero, Edith
Pereira-Suárez, Ana Laura
Bernard-Medina, Ana Guilaisne
المصدر
International Journal of Genomics
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-22
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Rheumatoid arthritis (RA) is an autoimmune disease characterized by the presence of antibodies against cyclic citrullinated peptide (anti-CCP), a consequence of the breakdown of immune tolerance.
The lymphoid tyrosine phosphatase (Lyp) protein has significant effects on maintenance of peripheral immune tolerance.
Two polymorphic variants (−1123G>C and +1858C>T) at PTPN22 gene that encodes this protein have been associated with autoimmune disorders and found in strong linkage disequilibrium in Caucasian population.
We evaluated whether PTPN22 haplotypes (−1123G>C/+1858C>T) are associated with anti-CCP antibodies, as well as susceptibility to RA in a Western Mexican population.
A total of 315 RA patients and 315 control subjects (CS) were included.
The polymorphisms were genotyped by PCR-RFLP and the anti-CCP antibodies were determined by ELISA.
The PTPN22 polymorphisms were in strong linkage disequilibrium (D′ = 1.00 in CS).
The susceptibility haplotype CT was significantly more frequent in RA patients than in CS (OR 2.18, 95% CI 1.15–4.16, p=0.01).
No association between haplotypes and anti-CCP antibodies levels was observed.
In conclusion, this study confirmed that −1123G>C and +1858C>T PTPN22 polymorphisms are in strong linkage disequilibrium and the CT haplotype is a susceptibility marker to RA in Western Mexico.
However, the PTPN22 haplotypes are not associated with anti-CCP antibodies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ruiz-Noa, Yeniley& Padilla-Gutiérrez, Jorge Ramón& Hernández-Bello, Jorge& Palafox-Sánchez, Claudia Azucena& Valle, Yeminia& Oregón-Romero, Edith…[et al.]. 2017. Association of PTPN22 Haplotypes (−1123G>C+1858C>T) with Rheumatoid Arthritis in Western Mexican Population. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1167262
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ruiz-Noa, Yeniley…[et al.]. Association of PTPN22 Haplotypes (−1123G>C+1858C>T) with Rheumatoid Arthritis in Western Mexican Population. International Journal of Genomics No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1167262
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ruiz-Noa, Yeniley& Padilla-Gutiérrez, Jorge Ramón& Hernández-Bello, Jorge& Palafox-Sánchez, Claudia Azucena& Valle, Yeminia& Oregón-Romero, Edith…[et al.]. Association of PTPN22 Haplotypes (−1123G>C+1858C>T) with Rheumatoid Arthritis in Western Mexican Population. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1167262
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1167262
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر