HCV Integrated Care: A Randomized Trial to Increase Treatment Initiation and SVR with Direct Acting Antivirals
المؤلفون المشاركون
Ho, Samuel B.
Groessl, Erik J.
Liu, Lin
Sklar, Marisa
المصدر
International Journal of Hepatology
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-27
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background and Aims.
Psychiatric or substance use disorders are barriers to successful HCV antiviral treatment.
In a randomized, controlled trial (RCT), the effects of HCV Integrated Care (IC) for increasing treatment rates and sustained viral response (SVR) were studied with direct acting antivirals (DAA).
Methods.
In 2012-13, VA patients, whose screening was positive for depression, PTSD, or substance use (N=79), were randomized to IC or Usual Care (UC).
IC consisted of brief psychological interventions and case management.
The primary endpoint was SVR among patients followed for an average of 16.6 months.
Results.
42% of the study participants were previously homeless and 79% had HCV genotype 1.
Twice as many IC participants (45%) initiated treatment compared with UC participants (23%) (χ2 = 4.59, p=0.032).
Among those treated, SVR rates did not significantly differ (IC: 12/18 = 67%; UC: 5/9 = 55%; p=0.23).
Among all randomized participants, IC participants trended toward better SVR rates (30.0% versus 12.8% in UC; p=0.07).
Conclusions.
Although first-generation DAAs are no longer used, this smaller RCT helps confirm the results of a larger multisite RCT showing that Integrated Care results in higher treatment initiation and SVR rates among HCV-infected persons with comorbid psychological disorders.
Integrated mental health services can facilitate treatment among the most challenging HCV patients, many of whom have not been successfully treated.
This trial is registered with ClinicalTrials.gov number NCT00722423.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Groessl, Erik J.& Liu, Lin& Sklar, Marisa& Ho, Samuel B.. 2017. HCV Integrated Care: A Randomized Trial to Increase Treatment Initiation and SVR with Direct Acting Antivirals. International Journal of Hepatology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1167329
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Groessl, Erik J.…[et al.]. HCV Integrated Care: A Randomized Trial to Increase Treatment Initiation and SVR with Direct Acting Antivirals. International Journal of Hepatology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1167329
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Groessl, Erik J.& Liu, Lin& Sklar, Marisa& Ho, Samuel B.. HCV Integrated Care: A Randomized Trial to Increase Treatment Initiation and SVR with Direct Acting Antivirals. International Journal of Hepatology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1167329
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1167329
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر