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Analytical Method Development for Sodium Valproate through Chemical Derivatization
المؤلفون المشاركون
Abualhasan, Murad N.
Odeh, Nihaya Wasif
Younis, Ghadeer Naser
Zeidan, Oyoun Fadel
المصدر
International Journal of Analytical Chemistry
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Sodium valproate has anticonvulsant activity and is structurally different to conventional antiepileptic drugs.
The problem with valproic acid is the lack of a chromophore, which means that gas chromatography is the sole assay methodology.
The introduction of benzoyl and phenyl groups to the molecule is a useful derivatisation, which enables the creation of detectable chromophores for HPLC analysis for pharmaceutical dosages as well as biological systems.
Methodology.
Sodium valproate was derivatised by the addition of a chromophore to its structure by introducing a methyl benzoyl or a phenyl group.
Trichlorophenol and 2-hydroxyacetophenone were used to introduce phenyl and benzoyl groups to valproic acid, respectively.
The reaction used was estrification reaction using coupling agents.
An analytical method was then developed and validated using reverse-phase HPLC.
The method was validated for parameters like linearity, range, accuracy precision, and robustness.
Results.
The developed method was easy and feasible and can be applied to both routine analysis and bioanalysis.
The method was very sensitive and could quantify valproic acid at a very low concentration of 0.75 × 10−5 mg/ml.
The developed method was found to be linear (R2 = 0.997), accurate, precise, and robust.
Conclusion.
The proposed chemical derivatisation and the developed analytical method are novel.
The developed analytical procedure is the first of its kind; it is easy and feasible and can be used to quantify and detect sodium valproate at very low concentrations compared to other available methods in the literature.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abualhasan, Murad N.& Odeh, Nihaya Wasif& Younis, Ghadeer Naser& Zeidan, Oyoun Fadel. 2020. Analytical Method Development for Sodium Valproate through Chemical Derivatization. International Journal of Analytical Chemistry،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1167664
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abualhasan, Murad N.…[et al.]. Analytical Method Development for Sodium Valproate through Chemical Derivatization. International Journal of Analytical Chemistry No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1167664
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abualhasan, Murad N.& Odeh, Nihaya Wasif& Younis, Ghadeer Naser& Zeidan, Oyoun Fadel. Analytical Method Development for Sodium Valproate through Chemical Derivatization. International Journal of Analytical Chemistry. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1167664
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1167664
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