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Study on the Role of the Inclusion Complexes with 2-Hydroxypropyl-β-cyclodextrin for Oral Administration of Amiodarone
المؤلفون المشاركون
Ochiuz, Lăcrămioara
Creteanu, Andreea
Pamfil, Daniela
Tantaru, Gladiola
Ghiciuc, Cristina Mihaela
Ghilan, Alina
Macsim, Ana Maria
Vasile, Cornelia
المصدر
International Journal of Polymer Science
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-23، 23ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-28
دولة النشر
مصر
عدد الصفحات
23
التخصصات الرئيسية
الملخص EN
The aim of this study was to improve the solubility of amiodarone hydrochloride (AMD) and the drug release using its inclusion complexes with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD).
The inclusion complexes were prepared by coprecipitation and freeze-drying.
The solubility enhancement of AMD/HP-β-CD inclusion complexes by 4–22 times was evaluated by the phase solubility method.
The inclusion complexes were studied both in solution and in solid state by spectroscopic methods, dynamic light scattering (DLS) and zeta potential analysis, SEM, and DSC.
The formulations of AMD/HP-β-CD inclusion complexes both as powdered form and as matrix tablets showed superior pharmacokinetic performance in improving loading and release properties in respect of those of the insoluble AMD drug.
In vitro kinetic study reveals a complex mechanism of release occurring in three steps: the first one being attributed to a burst effect and the other two to different bonding existing in inclusion complexes.
An in vivo test on matrix tablets containing Kollidon® and chitosan also reveals a multiple (at least two) peaks release diagram because of both structures of the inclusion complexes and also of different sites of absorption in biological media (digestive tract).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Creteanu, Andreea& Pamfil, Daniela& Vasile, Cornelia& Tantaru, Gladiola& Ghiciuc, Cristina Mihaela& Ochiuz, Lăcrămioara…[et al.]. 2019. Study on the Role of the Inclusion Complexes with 2-Hydroxypropyl-β-cyclodextrin for Oral Administration of Amiodarone. International Journal of Polymer Science،Vol. 2019, no. 2019, pp.1-23.
https://search.emarefa.net/detail/BIM-1167745
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Creteanu, Andreea…[et al.]. Study on the Role of the Inclusion Complexes with 2-Hydroxypropyl-β-cyclodextrin for Oral Administration of Amiodarone. International Journal of Polymer Science No. 2019 (2019), pp.1-23.
https://search.emarefa.net/detail/BIM-1167745
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Creteanu, Andreea& Pamfil, Daniela& Vasile, Cornelia& Tantaru, Gladiola& Ghiciuc, Cristina Mihaela& Ochiuz, Lăcrămioara…[et al.]. Study on the Role of the Inclusion Complexes with 2-Hydroxypropyl-β-cyclodextrin for Oral Administration of Amiodarone. International Journal of Polymer Science. 2019. Vol. 2019, no. 2019, pp.1-23.
https://search.emarefa.net/detail/BIM-1167745
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1167745
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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