Functional Graphene Oxide Nanocarriers for Drug Delivery

المؤلفون المشاركون

Ye, Yuanfeng
Kong, Jingyang
Mao, Xincheng
Xu, Jialing
Zhang, Guojun

المصدر

International Journal of Polymer Science

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-01-31

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الفيزياء

الملخص EN

The family of graphene has attracted increasing attention on account of their large specific surface area and good mechanical properties in the biomedical field.

However, some characteristics like targeted delivery property and drug delivery capacity could not satisfy the need of a drug carrier.

Herein, a graphene oxide (GO) nanocarrier was designed by modification of a folic acid (FA) derivative and a β-cyclodextrin (β-CD) derivative in order to improve two properties, respectively.

In the first step, reactive or crosslinkable FA and aldehydic β-CD (β-CD-CHO) were designed and synthesized for further modification.

In the second step, synthesized functional molecules were coupled onto GO sheets one by one to obtain the GO nanocarrier.

IR spectra and XRD results were used to identify the chemical and structural information before and after modification for the GO nanocarrier.

The final GO nanocarrier exhibited a typical thin wrinkled sheet morphology of the GO sheet without any influence by two functional molecules.

Finally, in vitro evaluation was used to clarify the drug loading and controlling capacity of the nanocarrier as a drug delivery system.

The results revealed that the GO nanocarrier had a better CPT loading capacity and showed better controllability for CPT release.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Ye, Yuanfeng& Mao, Xincheng& Xu, Jialing& Kong, Jingyang& Zhang, Guojun. 2019. Functional Graphene Oxide Nanocarriers for Drug Delivery. International Journal of Polymer Science،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1168308

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Ye, Yuanfeng…[et al.]. Functional Graphene Oxide Nanocarriers for Drug Delivery. International Journal of Polymer Science No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1168308

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Ye, Yuanfeng& Mao, Xincheng& Xu, Jialing& Kong, Jingyang& Zhang, Guojun. Functional Graphene Oxide Nanocarriers for Drug Delivery. International Journal of Polymer Science. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1168308

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1168308