Mathematical Modelling of Acetaminophen Release in HPCPAAm Hydrogel: Synthesis and Application
المؤلفون المشاركون
Morales-Cepeda, A. B.
Castillo-Miranda, Claudia Alicia
Castro-Guerrero, Carlos Fernando
Díaz-Guerrero, Abigail M.
Peraza-Vázquez, Hernán
Peña-Delgado, Adrián F.
المصدر
International Journal of Polymer Science
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-18
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Hydrogels are commonly used as Drug Delivery Systems (DDS) as patches due to its ability to store drug molecules within their structures.
The release can be activated under certain stimuli, such as temperature and pH.
In this paper, the mathematical modelling of acetaminophen release in hydroxypropyl cellulose with polyacrylamide (HPC/PAAm) is reported.
The HPC/PAAm gel was synthesized in proportions of 25/75 wt% and was characterized by FTIR, DSC, optical microscopy, SEM, and TGA, with and without acetaminophen.
The release tests were performed for hypothermic, normal, and febrile human body conditions, at 35, 37, and 39°C, respectively, on two release media: water and phosphate buffer solution.
In order to describe the release of acetaminophen in HPC/PAAm gel, a genetic programming algorithm was used to accomplish Multigene Symbolic Regression (MSR).
Characterization results showed that the drug was crystallized on the surface of the HPC/PAAm gel.
Release test results showed that several simultaneous processes occurred in the acetaminophen diffusion phenomenon.
A unique mathematical model was obtained by MSR.
This model was able to describe the release of acetaminophen in HPC/PAAm gel with high values of R2 and adjusted R2 and to simulate the drug release at times beyond the end of the experiment.
High values of R2 and low values of Coefficient of Variation (CV), Root-Mean-Square Error (RMSE), and Mean Absolute Error (MAE) were obtained from the comparison between the simulated and the experimental data.
This allows to conclude that the mathematical model is reliable to represent and simulate the acetaminophen release in HPC/PAAm gel at 35, 37, and 39°C.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Díaz-Guerrero, Abigail M.& Castillo-Miranda, Claudia Alicia& Castro-Guerrero, Carlos Fernando& Peraza-Vázquez, Hernán& Morales-Cepeda, A. B.& Peña-Delgado, Adrián F.. 2019. Mathematical Modelling of Acetaminophen Release in HPCPAAm Hydrogel: Synthesis and Application. International Journal of Polymer Science،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1168385
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Díaz-Guerrero, Abigail M.…[et al.]. Mathematical Modelling of Acetaminophen Release in HPCPAAm Hydrogel: Synthesis and Application. International Journal of Polymer Science No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1168385
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Díaz-Guerrero, Abigail M.& Castillo-Miranda, Claudia Alicia& Castro-Guerrero, Carlos Fernando& Peraza-Vázquez, Hernán& Morales-Cepeda, A. B.& Peña-Delgado, Adrián F.. Mathematical Modelling of Acetaminophen Release in HPCPAAm Hydrogel: Synthesis and Application. International Journal of Polymer Science. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1168385
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1168385
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر