Increased Tissue Penetration of Doxorubicin in Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) after High-Intensity Ultrasound (HIUS)
المؤلفون المشاركون
Khosrawipour, Veria
Reinhard, Sören
Martino, Alice
Khosrawipour, Tanja
Arafkas, Mohamed
Mikolajczyk, Agata
المصدر
International Journal of Surgical Oncology
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-12
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
High‐intensity ultrasound (HIUS) has been studied for the past two decades as a new therapeutic option for solid tumor direct treatment and a method for better chemotherapy delivery and perfusion.
This treatment approach has not been tested to our knowledge in peritoneal metastatic therapy, where limited tissue penetration of intraperitoneal chemotherapy has been a main problem.
Both liquid instillations and pressurized aerosols are affected by this limitation.
This study was performed to evaluate whether HIUS improves chemotherapy penetration rates.
Methods.
High-intensity ultrasound (HIUS) was applied for 0, 5, 30, 60, 120, and 300 seconds on the peritoneal tissue samples from fresh postmortem swine.
Samples were then treated with doxorubicin via pressurized intraperitoneal aerosol chemotherapy (PIPAC) under 12 mmHg and 37°C temperature.
Tissue penetration of doxorubicin was measured using fluorescence microscopy on frozen thin sections.
Results.
Macroscopic structural changes, identified by swelling of the superficial layer of the peritoneal surface, were observed after 120 seconds of HIUS.
Maximum doxorubicin penetration was significantly higher in peritoneum treated with HIUS for 300 seconds, with a depth of 962.88 ± 161.4 μm (p < 0.05).
Samples without HIUS had a penetration depth of 252.25 ± 60.41.
Tissue penetration was significantly increased with longer HIUS duration, with up to 3.8-fold increased penetration after 300 sec of HIUS treatment.
Conclusion.
Our data indicate that HIUS may be used as a method to prepare the peritoneal tissue for intraperitoneal chemotherapy.
Higher tissue penetration rates can be achieved without increasing chemotherapy concentrations and preventing structural damage to tissue using short time intervals.
More studies need to be performed to analyze the effect of HIUS in combination with intraperitoneal chemotherapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khosrawipour, Veria& Reinhard, Sören& Martino, Alice& Khosrawipour, Tanja& Arafkas, Mohamed& Mikolajczyk, Agata. 2019. Increased Tissue Penetration of Doxorubicin in Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) after High-Intensity Ultrasound (HIUS). International Journal of Surgical Oncology،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1168660
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khosrawipour, Veria…[et al.]. Increased Tissue Penetration of Doxorubicin in Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) after High-Intensity Ultrasound (HIUS). International Journal of Surgical Oncology No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1168660
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khosrawipour, Veria& Reinhard, Sören& Martino, Alice& Khosrawipour, Tanja& Arafkas, Mohamed& Mikolajczyk, Agata. Increased Tissue Penetration of Doxorubicin in Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) after High-Intensity Ultrasound (HIUS). International Journal of Surgical Oncology. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1168660
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1168660
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر