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Pulmonary Complications Secondary to Immune Checkpoint Inhibitors
المؤلفون المشاركون
Duma, Narjust
Albitar, Hasan Ahmad Hasan
Leventakos, Konstantinos
Gallo De Moraes, Alice
المصدر
International Journal of Chronic Diseases
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-24
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Immune checkpoint inhibitors (ICI) have changed the landscape in the treatment of a number of cancers.
Immune-related adverse events (irAEs) have emerged as a serious clinical problem with the use of ICI.
Methods.
All oncology patients diagnosed with pulmonary complications secondary to ICI at Mayo Clinic Rochester from January 1, 2012 to December 31, 2018 were reviewed.
Demographics, comorbidities, smoking, and oncologic history were analyzed.
Results.
A total of 10 patients developed pulmonary complications secondary to ICI.
Seven patients were men (70%), and the median age at diagnosis was 61.5 (IQR 55.8-69.3) years.
All patients had stage IV disease.
Melanoma was the most common malignancy.
Seven (70%) patients had a positive smoking history, and 6 (60%) were obese (BMI>30).
Most cases were grade 2 pneumonitis (70%).
One patient with grade 4 pneumonitis required endotracheal intubation and a prolonged course of systemic corticosteroids (>30 days).
Eight (80%) patients received prior radiation therapy.
The median time from initiation of ICI to pneumonitis diagnosis was 3.5 months.
Conclusion.
Melanoma was the most common malignancy, the majority of patients had grade 2 pneumonitis and required treatment with steroids, and all patients affected by ICI-related pneumonitis had stage IV malignancy.
Potential risk factors included smoking history, prior radiotherapy, obesity, and advance stage at the time of ICI initiation.
Extrapulmonary irAEs are common in patients with pneumonitis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Albitar, Hasan Ahmad Hasan& Duma, Narjust& Leventakos, Konstantinos& Gallo De Moraes, Alice. 2020. Pulmonary Complications Secondary to Immune Checkpoint Inhibitors. International Journal of Chronic Diseases،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1169303
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Albitar, Hasan Ahmad Hasan…[et al.]. Pulmonary Complications Secondary to Immune Checkpoint Inhibitors. International Journal of Chronic Diseases No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1169303
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Albitar, Hasan Ahmad Hasan& Duma, Narjust& Leventakos, Konstantinos& Gallo De Moraes, Alice. Pulmonary Complications Secondary to Immune Checkpoint Inhibitors. International Journal of Chronic Diseases. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1169303
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1169303
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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