Method Validation for Progesterone Determination in Poly(methyl methacrylate) Nanoparticles Synthesized via Miniemulsion Polymerization
المؤلفون المشاركون
Fogolari, Odinei
Felippe, Arlindo Cristiano
Leimann, Fernanda Vitória
Gonçalves, Odinei Hess
Sayer, Claudia
Araújo, Pedro Henrique Hermes De
المصدر
International Journal of Polymer Science
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-01
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Exogenous progesterone has several applications in human health and in veterinary medicine, especially in fixed-time artificial insemination protocol.
Progesterone nanoencapsulation in biocompatible polymers, such as poly(methyl methacrylate) (PMMA), is an alternative to substitute silicone-based release device traditionally used for estrus control.
Progesterone concentration inside the nanoparticles must be precisely known; for that reason, a validation methodology must be applied to ensure reliable results, suitable for nanoparticles application.
In this work, an UV-Vis spectrophotometric method was validated for the determination of progesterone in PMMA nanoparticles synthesized by miniemulsion polymerization.
Chloroform was used as solvent, showing selectivity to the encapsulated drug and the components of the polymeric matrix did not influence progesterone recovery.
Detection and quantitation limits (DL and QL) obtained were 0.32 and 0.96 mg·L−1, respectively, and precision tests (between different analysts and equipment) indicated acceptable Relative Standard Deviations (RSD < 5%).
Miniemulsion polymerization reactions were carried out producing two different morphologies: nanospheres (NS) and nanocapsules (NC), with average intensity diameters (Dz) of 150–200 nm and 240–300 nm, respectively.
Polymerization gravimetric conversions obtained for both cases were higher than 95% and encapsulation efficiencies greater than 69% and 90% for the nanospheres and nanocapsules, respectively.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fogolari, Odinei& Felippe, Arlindo Cristiano& Leimann, Fernanda Vitória& Gonçalves, Odinei Hess& Sayer, Claudia& Araújo, Pedro Henrique Hermes De. 2017. Method Validation for Progesterone Determination in Poly(methyl methacrylate) Nanoparticles Synthesized via Miniemulsion Polymerization. International Journal of Polymer Science،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1169305
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fogolari, Odinei…[et al.]. Method Validation for Progesterone Determination in Poly(methyl methacrylate) Nanoparticles Synthesized via Miniemulsion Polymerization. International Journal of Polymer Science No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1169305
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fogolari, Odinei& Felippe, Arlindo Cristiano& Leimann, Fernanda Vitória& Gonçalves, Odinei Hess& Sayer, Claudia& Araújo, Pedro Henrique Hermes De. Method Validation for Progesterone Determination in Poly(methyl methacrylate) Nanoparticles Synthesized via Miniemulsion Polymerization. International Journal of Polymer Science. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1169305
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1169305
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر