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The Use of Sentinel Lymph Node Biopsy in BRCA12 Mutation Carriers Undergoing Prophylactic Mastectomy: A Retrospective Consecutive Case-Series Study
المؤلفون المشاركون
Câmara, S.
Pereira, Daniela
André, Saudade
Mira, Beatriz
Vaz, Fátima
Oom, Rodrigo
Marques, José Carlos
Leal de Faria, João
Rodrigues dos Santos, Catarina
المصدر
International Journal of Breast Cancer
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-01
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Introduction.
Sentinel lymph node biopsy in prophylactic mastectomy is controversial.
It avoids lymphadenectomy in occult carcinoma but is associated with increased morbidity.
Women with BRCA mutations have a higher incidence of occult carcinoma and our objective was to assess the clinical utility of sentinel lymph node biopsy when these women undergo prophylactic mastectomy.
Materials and Methods.
Seven-year retrospective consecutive case-series study of women, with a BRCA deleterious mutation, admitted to prophylactic mastectomy, at our center.
Breast MRI < 6 months before surgery was routine, unless contraindicated.
Results.
Fifty-seven patients (43% BRCA1; 57% BRCA2) underwent 80 prophylactic mastectomies.
72% of patients had had breast cancer treated before prophylactic mastectomy or synchronously to it.
The occult carcinoma incidence was 5%, and half of the cases were invasive.
SLNB was performed in 19% of the prophylactic mastectomies; none of these had tumor invasion.
Women with invasive carcinoma who had not undergone sentinel lymph node biopsy were followed closely with axillary ultrasound.
The median follow-up was 37 months, with no local recurrence; 1 patient died of primary tumor systemic relapse.
Conclusions.
Our data do not support this procedure for routine (in agreement with previous literature), in this high risk for occult carcinoma population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Câmara, S.& Pereira, Daniela& André, Saudade& Mira, Beatriz& Vaz, Fátima& Oom, Rodrigo…[et al.]. 2018. The Use of Sentinel Lymph Node Biopsy in BRCA12 Mutation Carriers Undergoing Prophylactic Mastectomy: A Retrospective Consecutive Case-Series Study. International Journal of Breast Cancer،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1169420
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Câmara, S.…[et al.]. The Use of Sentinel Lymph Node Biopsy in BRCA12 Mutation Carriers Undergoing Prophylactic Mastectomy: A Retrospective Consecutive Case-Series Study. International Journal of Breast Cancer No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1169420
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Câmara, S.& Pereira, Daniela& André, Saudade& Mira, Beatriz& Vaz, Fátima& Oom, Rodrigo…[et al.]. The Use of Sentinel Lymph Node Biopsy in BRCA12 Mutation Carriers Undergoing Prophylactic Mastectomy: A Retrospective Consecutive Case-Series Study. International Journal of Breast Cancer. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1169420
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1169420
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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