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The Effects of Lutein and Zeaxanthin Supplementation on Brain Morphology in Older Adults: A Randomized, Controlled Trial
المؤلفون المشاركون
Miller, L. Stephen
Mewborn, Catherine M.
Lindbergh, Cutter A.
Renzi-Hammond, Lisa M.
Hammond, Billy R.
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-01
دولة النشر
مصر
عدد الصفحات
11
الملخص EN
A growing literature emphasizes the importance of lifestyle factors such as nutrition in successful aging.
The current study examined if one year of supplementation with lutein (L) and zeaxanthin (Z), two nutrients with known antioxidative properties and cognitive benefits, impacted structural brain outcomes in older adults using a double-blind, randomized, placebo-controlled trial design.
Community-dwelling older adults (20 males and 27 females) aged 65–87 years (M = 71.8 years, SD = 6.04 years) were randomized into supplement (N = 33) and placebo groups (N = 14) using simple randomization.
The supplement group received 10 mg L + 2 mg Z daily for 12 months while the placebo group received a visually identical, inert placebo.
L and Z were measured via retinal concentrations (macular pigment optical density or MPOD).
Structural brain outcomes, focusing on global and frontal-temporal lobe regions, were acquired using both T1-weighted and DTI MRI sequences.
We hypothesized that the supplement group would increase, maintain, or show attenuated loss in hypothesized regions-of-interest (ROIs) while the placebo group would show age-related declines in brain structural integrity over the course of the trial.
While results showed age-related declines for frontal and temporal gray and white matter volumes, as well as fornix white matter microstructure across both groups, only minimal differences were found between the supplement and placebo groups.
However, exploratory analyses showed that individuals who responded better to supplementation (i.e., showed greater increases in MPOD) showed less decline in global and prefrontal gray matter volume than supplement “nonresponders.” While results suggest that one year of L and Z supplementation may have limited effects on structural brain outcomes overall, there may be a subsample of individuals for whom supplementation of L and Z provides greater benefits.
ClinicalTrials.gov number, NCT02023645.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mewborn, Catherine M.& Lindbergh, Cutter A.& Hammond, Billy R.& Renzi-Hammond, Lisa M.& Miller, L. Stephen. 2019. The Effects of Lutein and Zeaxanthin Supplementation on Brain Morphology in Older Adults: A Randomized, Controlled Trial. Journal of Aging Research،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1169426
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mewborn, Catherine M.…[et al.]. The Effects of Lutein and Zeaxanthin Supplementation on Brain Morphology in Older Adults: A Randomized, Controlled Trial. Journal of Aging Research No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1169426
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mewborn, Catherine M.& Lindbergh, Cutter A.& Hammond, Billy R.& Renzi-Hammond, Lisa M.& Miller, L. Stephen. The Effects of Lutein and Zeaxanthin Supplementation on Brain Morphology in Older Adults: A Randomized, Controlled Trial. Journal of Aging Research. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1169426
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1169426
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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