Prevention of Acute Radiation-Induced Skin Reaction with NPE® Camellia Sinensis Nonfermentatum Extract in Female Breast Cancer Patients Undergoing Postoperative Radiotherapy: A Single Centre, Prospective, Open-Label Pilot Study
المؤلفون المشاركون
Zwahlen, Daniel
Näf, Gabriela
Gasser, Urs E.
Holzgang, Hans E.
Schafroth, Sandra
Oehler, Christoph
المصدر
International Journal of Breast Cancer
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-02
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
To assess effectiveness of NPE, a proprietary Camellia sinensis nonfermentatum (CSNF) extract, in prevention and recovery of acute radiation-induced skin reaction (ARSR) and skin care during postoperative whole breast radiotherapy (RT).
Methods.
Twenty patients were enrolled in this single centre, prospective, open-label pilot study.
The outcomes of 20 prospective data sets were compared with 100 retrospectively collected matched data sets derived from hospital records.
The preventive CSNF gel (2.5%) was administered 1 to 2 hours before each session on the irradiated fields.
The care CSNF lotion (0.4%) was administered as 7-day pretreatment after each RT session, twice daily between RT sessions, and 4 to 8 weeks thereafter.
The control group was treated according to the hospital care guidelines.
The primary endpoint was time to ARSR ≥ Grade 2 (CTCAE v4.03); secondary endpoints were frequencies of ARSR grades 1, 2, 3, and 4, recovery of ARSR, frequencies of interruption and RT stop, complications and required rescue interventions, and tolerability of CSNF.
Results.
Time to ARSR ≥ G2 (censoring) was significantly longer (p = 0.014) in the CSNF group.
The hazard ratio was 2.33 (95% CI: 1.15–4.72), demonstrating a 50% decrease in the risk of developing ARSR ≥ G2.
There was a trend to faster recovery from ARSR G2 in the CSNF group (100% versus 47%; p = 0.078).
The proportion of patients requiring rescue treatment during RT and follow-up was markedly higher in the control compared to the CSNF group (1% to 51% versus 0% to 15%).
CSNF gel and lotion were well tolerated both during and after RT.
Conclusions.
This pilot study provides the first evidence on the potential pharmacological effectiveness of CSNF extract in prevention of RT-induced ARSR and recovery of skin irritation in patients undergoing postoperative whole breast RT and may reflect a novel concept for prevention of RT-induced ARSR and care of irritated skin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Näf, Gabriela& Gasser, Urs E.& Holzgang, Hans E.& Schafroth, Sandra& Oehler, Christoph& Zwahlen, Daniel. 2018. Prevention of Acute Radiation-Induced Skin Reaction with NPE® Camellia Sinensis Nonfermentatum Extract in Female Breast Cancer Patients Undergoing Postoperative Radiotherapy: A Single Centre, Prospective, Open-Label Pilot Study. International Journal of Breast Cancer،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1169434
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Näf, Gabriela…[et al.]. Prevention of Acute Radiation-Induced Skin Reaction with NPE® Camellia Sinensis Nonfermentatum Extract in Female Breast Cancer Patients Undergoing Postoperative Radiotherapy: A Single Centre, Prospective, Open-Label Pilot Study. International Journal of Breast Cancer No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1169434
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Näf, Gabriela& Gasser, Urs E.& Holzgang, Hans E.& Schafroth, Sandra& Oehler, Christoph& Zwahlen, Daniel. Prevention of Acute Radiation-Induced Skin Reaction with NPE® Camellia Sinensis Nonfermentatum Extract in Female Breast Cancer Patients Undergoing Postoperative Radiotherapy: A Single Centre, Prospective, Open-Label Pilot Study. International Journal of Breast Cancer. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1169434
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1169434
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر