Association between Virulence Factors and Extended Spectrum Beta-Lactamase Producing Klebsiella pneumoniae Compared to Nonproducing Isolates
المؤلفون المشاركون
Mostafa El-Mahdy, Areej
Gharrah, Mustafa Muhammad
Barwa, Rasha Fathy
المصدر
Interdisciplinary Perspectives on Infectious Diseases
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-08
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Klebsiella pneumoniae is considered an important opportunistic multidrug-resistant pathogen.
Extended spectrum β-lactamases (ESBLs) and expression of a multitude of virulence factors may work in a harmony resulting in treatment failure.
This study was undertaken to compare the virulence characteristics and genetic relatedness between ESBL and non-ESBL producing K.
pneumoniae.
Methods.
Antibiotic sensitivity test of all isolates was determined by disc diffusion assay.
Phenotypic and genotypic detection of ESBL were done.
Various virulence factors and some virulence factor-associated genes were screened.
Random amplified polymorphic DNA (RAPD) was employed to investigate the genetic fingerprints of ESBL from non-ESBL producing K.
pneumoniae.
Results.
50% of isolates were ESBL producers.
A significant association was observed between ESBL production and biofilm (strong and moderate), serum resistance, and iss gene.
Moreover, significant association between non-ESBL producers and hypermucoviscosity was identified.
Dendogram analysis of RAPD profile classified K.
pneumoniae isolates into four clusters (a, b, c, and d).
Seventy-six percent of ESBL producers belonged to cluster a.
In conclusion, this study suggests a correlation between ESBL production and some virulence factors.
Therefore, success of treatment depends mainly on increased clinicians awareness and enhanced testing by laboratories to reduce the spread of these isolates.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gharrah, Mustafa Muhammad& Mostafa El-Mahdy, Areej& Barwa, Rasha Fathy. 2017. Association between Virulence Factors and Extended Spectrum Beta-Lactamase Producing Klebsiella pneumoniae Compared to Nonproducing Isolates. Interdisciplinary Perspectives on Infectious Diseases،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1169855
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gharrah, Mustafa Muhammad…[et al.]. Association between Virulence Factors and Extended Spectrum Beta-Lactamase Producing Klebsiella pneumoniae Compared to Nonproducing Isolates. Interdisciplinary Perspectives on Infectious Diseases No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1169855
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gharrah, Mustafa Muhammad& Mostafa El-Mahdy, Areej& Barwa, Rasha Fathy. Association between Virulence Factors and Extended Spectrum Beta-Lactamase Producing Klebsiella pneumoniae Compared to Nonproducing Isolates. Interdisciplinary Perspectives on Infectious Diseases. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1169855
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1169855
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر