Tenofovir-Based Highly Active Antiretroviral Therapy Is Associated with Superior CD4 T Cells Repopulation Compared to Zidovudine-Based HAART in HIV 1 Infected Adults
المؤلفون المشاركون
Forkuo, Arnold Donkor
Badii, Vitus Sambo
Buabeng, Kwame Ohene
Agyarko Poku, Thomas
Boamah, Bright Boafo
Arhin, Stephen Mensah
Kpewou, Daniel Edem
المصدر
International Journal of Chronic Diseases
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-18
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Tenofovir-based highly active antiretroviral therapy (HAART) is one of the preferred first-line therapies in the management of HIV 1 infection.
Ghana has since 2014 adopted this recommendation; however there is paucity of scientific data that reflects the safety and efficacy of the tenofovir-based therapy compared to zidovudine in the Ghanaian health system.
This study sought to assess the comparative immune reconstitution potential between tenofovir and zidovudine-based HAART regimens, which includes lamivudine and efavirenz in combination therapy.
It also aimed to investigate the adverse drug reactions/events (ADREs) associated with pharmacotherapy with these agents in a total of 106 HAART naïve HIV patients.
The study included 80 patients in the tenofovir cohort while 26 patients were on the zidovudine regimen.
The occurrence of HIV comorbidities profile was assessed at diagnosis and throughout the study period.
The baseline CD4 T cells count of the participants was also assessed at diagnosis and repeated at a median period of five months (range 4–6 months), after commencing treatment with either tenofovir- or zidovudine-based HAART.
After five months of the HAART, the tenofovir cohort recorded higher CD4 T cell count change from baseline compared to the zidovudine cohort ( p < 0.0001 ).
The patients on the tenofovir-based HAART and female sex however appeared to be associated with more multiple ADREs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Badii, Vitus Sambo& Buabeng, Kwame Ohene& Agyarko Poku, Thomas& Forkuo, Arnold Donkor& Boamah, Bright Boafo& Arhin, Stephen Mensah…[et al.]. 2018. Tenofovir-Based Highly Active Antiretroviral Therapy Is Associated with Superior CD4 T Cells Repopulation Compared to Zidovudine-Based HAART in HIV 1 Infected Adults. International Journal of Chronic Diseases،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1170028
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Badii, Vitus Sambo…[et al.]. Tenofovir-Based Highly Active Antiretroviral Therapy Is Associated with Superior CD4 T Cells Repopulation Compared to Zidovudine-Based HAART in HIV 1 Infected Adults. International Journal of Chronic Diseases No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1170028
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Badii, Vitus Sambo& Buabeng, Kwame Ohene& Agyarko Poku, Thomas& Forkuo, Arnold Donkor& Boamah, Bright Boafo& Arhin, Stephen Mensah…[et al.]. Tenofovir-Based Highly Active Antiretroviral Therapy Is Associated with Superior CD4 T Cells Repopulation Compared to Zidovudine-Based HAART in HIV 1 Infected Adults. International Journal of Chronic Diseases. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1170028
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1170028
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر