Reduction of Liver Span and Parameters of Inflammation in Nonalcoholic Fatty Liver Disease Patients Treated with Lycosome Formulation of Phosphatidylcholine: A Preliminary Report
المؤلفون المشاركون
Bashmakov, Yuriy K.
Chalyk, Natalia E.
Dovgalevsky, Pavel Y.
Klochkov, Victor A.
Petyaev, Ivan M.
Kyle, Nigel
المصدر
International Journal of Chronic Diseases
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-01
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Twenty-nine newly diagnosed individuals with Nonalcoholic Fatty Liver Disease (NAFLD) remaining on habitual dietary regimen were supplemented with regular or lycosome formulations of phosphatidylcholine (PC) during a pilot, randomized, double-blinded clinical study.
After two months of oral PC intake (450 mg daily) the liver size as well as serum levels of hepatic enzymes and markers of inflammation were evaluated by ultrasonography and biochemical analysis.
It was shown that there was a statistically significant reduction of medians for the Mid-Clavicular liver size from 16.0 cm (95/5% CI: 17.1/15.5) to 15.1 cm (95/5% CI: 17.2/14.4, P=0.021) in participants ingesting the lycosome-formulated PC (L-PC) whereas regular formulation of PC (R-PC) had only a marginal effect on this parameter (P=0.044).
A similar tendency was observed in the Mid-Sternal liver size.
Moreover, there was a reduction of medians for ALT values at the end point of the study (P=0.026) after ingestion of L-PC, while R-PC had no statistically significant effect.
On the other hand, ingestion of both formulations was accompanied by reductions in values for Inflammatory Oxidative Damage (IOD) and oxidized LDL in serum.
However, L-PC had superior activity in these terms, presumably due to the presence of lycopene, a powerful antioxidant, in the L-PC-Lycosome structure.
C-reactive protein level was moderately decreased (reduction of medians from 6.5 [95/5% CI: 7.7/5.8] mg/L to 5.1 [95/5% CI: 5.6/4.3] mg/L) only after ingestion of L-PC.
The greater efficacy of L-PC seen in NAFLD volunteers may reflect improved bioavailability of PC owing to better protection of the microencapsulated PC from gastrointestinal enzymes and possibly enhanced hepatic delivery of L-PC particles.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Petyaev, Ivan M.& Dovgalevsky, Pavel Y.& Chalyk, Natalia E.& Klochkov, Victor A.& Kyle, Nigel& Bashmakov, Yuriy K.. 2018. Reduction of Liver Span and Parameters of Inflammation in Nonalcoholic Fatty Liver Disease Patients Treated with Lycosome Formulation of Phosphatidylcholine: A Preliminary Report. International Journal of Chronic Diseases،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1170033
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Petyaev, Ivan M.…[et al.]. Reduction of Liver Span and Parameters of Inflammation in Nonalcoholic Fatty Liver Disease Patients Treated with Lycosome Formulation of Phosphatidylcholine: A Preliminary Report. International Journal of Chronic Diseases No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1170033
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Petyaev, Ivan M.& Dovgalevsky, Pavel Y.& Chalyk, Natalia E.& Klochkov, Victor A.& Kyle, Nigel& Bashmakov, Yuriy K.. Reduction of Liver Span and Parameters of Inflammation in Nonalcoholic Fatty Liver Disease Patients Treated with Lycosome Formulation of Phosphatidylcholine: A Preliminary Report. International Journal of Chronic Diseases. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1170033
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1170033
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر