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Calcitonin and Bone Physiology: In Vitro, In Vivo, and Clinical Investigations
المؤلفون المشاركون
Guo, Jian
Li, Ping
Buabeid, Manal Ali
Arafa, El-Shaimaa A.
Xie, Jingbo
Kanwal, Zaeema
Wu, Mingzheng
Lv, Xiangyang
Ibrahim, Nihal Abdalla
Sun, Qingshan
المصدر
International Journal of Endocrinology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-10
دولة النشر
مصر
عدد الصفحات
20
التخصصات الرئيسية
الملخص EN
Calcitonin was discovered as a peptide hormone that was known to reduce the calcium levels in the systemic circulation.
This hypocalcemic effect is produced due to multiple reasons such as inhibition of bone resorption or suppression of calcium release from the bone.
Thus, calcitonin was said as a primary regulator of the bone resorption process.
This is the reason why calcitonin has been used widely in clinics for the treatment of bone disorders such as osteoporosis, hypercalcemia, and Paget’s disease.
However, presently calcitonin usage is declined due to the development of efficacious formulations of new drugs.
Calcitonin gene-related peptides and several other peptides such as intermedin, amylin, and adrenomedullin (ADM) are categorized in calcitonin family.
These peptides are known for the structural similarity with calcitonin.
Aside from having a similar structure, these peptides have few overlapping biological activities and signal transduction action through related receptors.
However, several other activities are also present that are peptide specific.
In vitro and in vivo studies documented the posttreatment effects of calcitonin peptides, i.e., positive effect on bone osteoblasts and their formation and negative effect on osteoclasts and their resorption.
The recent research studies carried out on genetically modified mice showed the inhibition of osteoclast activity by amylin, while astonishingly calcitonin plays its role by suppressing osteoblast and bone turnover.
This article describes the review of the bone, the activity of the calcitonin family of peptides, and the link between them.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xie, Jingbo& Guo, Jian& Kanwal, Zaeema& Wu, Mingzheng& Lv, Xiangyang& Ibrahim, Nihal Abdalla…[et al.]. 2020. Calcitonin and Bone Physiology: In Vitro, In Vivo, and Clinical Investigations. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-20.
https://search.emarefa.net/detail/BIM-1170225
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xie, Jingbo…[et al.]. Calcitonin and Bone Physiology: In Vitro, In Vivo, and Clinical Investigations. International Journal of Endocrinology No. 2020 (2020), pp.1-20.
https://search.emarefa.net/detail/BIM-1170225
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xie, Jingbo& Guo, Jian& Kanwal, Zaeema& Wu, Mingzheng& Lv, Xiangyang& Ibrahim, Nihal Abdalla…[et al.]. Calcitonin and Bone Physiology: In Vitro, In Vivo, and Clinical Investigations. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-20.
https://search.emarefa.net/detail/BIM-1170225
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1170225
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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