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The Effect of Metformin on Polycystic Ovary Syndrome in Overweight Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
المؤلفون المشاركون
Bu, Huaien
Guan, Yuanyuan
Wang, Dongjun
Zhao, Tieniu
Wang, Hongwu
المصدر
International Journal of Endocrinology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-16
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Objective.
Metformin is an important component of PCOS treatment.
At present, the effect of metformin in overweight women with PCOS has not been evaluated.
Therefore, we conducted a systematic review to assess the effects of metformin in overweight women with PCOS and to analyze the effects of metformin in overweight women with PCOS.
Methods.
We searched the PubMed, Cochrane Library, Embase, CNKI, VIP, and Wanfang databases for studies published before March 2020.
Randomized controlled trials were identified to study the effects of metformin in overweight women with PCOS.
Data from studies including body mass index (BMI), waist circumference (WC), follicle-stimulating hormone (FSH), homeostasis model assessment of insulin resistance (HOMA-IR), luteinizing hormone (LH), sex hormone-binding globulin (SHBG), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, total cholesterol (TC), triglycerides (TG), fasting blood glucose (FBG), fasting insulin, testosterone, and androstenedione were pooled.
Qualified trials were selected, and methodological quality was strictly assessed.
Two reviewers chose the studies independently of each other.
Results.
Twelve trials were included.
The intervention group and the control group had significant differences in the changes in body mass index (BMI) (WMD = −1.25, 95% CI (−1.60, −0.91), p<0.00001) and waist circumference (WC) (WMD = −1.41, 95% CI (−2.46, −0.37), p=0.008) after metformin.
The comprehensive results show that, in all studies, overweight women with polycystic ovary syndrome treated with metformin had significantly improved endocrine and metabolic indicators, including testosterone, follicle-stimulating hormone, luteinizing hormone, and low-density lipoprotein cholesterol.
However, metformin did not regulate the secretion indexes of fasting insulin, homeostasis model assessment of insulin resistance, sex hormone-binding globulin, high-density lipoprotein cholesterol, total cholesterol, triglycerides, fasting blood glucose, and androstenedione.
Conclusions.
Compared with control interventions, metformin appears to be an effective intervention for overweight women with PCOS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guan, Yuanyuan& Wang, Dongjun& Bu, Huaien& Zhao, Tieniu& Wang, Hongwu. 2020. The Effect of Metformin on Polycystic Ovary Syndrome in Overweight Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1170340
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guan, Yuanyuan…[et al.]. The Effect of Metformin on Polycystic Ovary Syndrome in Overweight Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. International Journal of Endocrinology No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1170340
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guan, Yuanyuan& Wang, Dongjun& Bu, Huaien& Zhao, Tieniu& Wang, Hongwu. The Effect of Metformin on Polycystic Ovary Syndrome in Overweight Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1170340
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1170340
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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