Semiautomated Alignment of High-Throughput Metabolite Profiles with Chemometric Tools
المؤلفون المشاركون
Mok, Daniel Kam-wah
Wu, Ze-ying
Zeng, Zhong-da
Xiao, Zi-dan
Liang, Yi-zeng
Chau, Foo-tim
Chan, Hoi-yan
المصدر
Journal of Analytical Methods in Chemistry
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-12
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The rapid increase in the use of metabolite profiling/fingerprinting techniques to resolve complicated issues in metabolomics has stimulated demand for data processing techniques, such as alignment, to extract detailed information.
In this study, a new and automated method was developed to correct the retention time shift of high-dimensional and high-throughput data sets.
Information from the target chromatographic profiles was used to determine the standard profile as a reference for alignment.
A novel, piecewise data partition strategy was applied for the determination of the target components in the standard profile as markers for alignment.
An automated target search (ATS) method was proposed to find the exact retention times of the selected targets in other profiles for alignment.
The linear interpolation technique (LIT) was employed to align the profiles prior to pattern recognition, comprehensive comparison analysis, and other data processing steps.
In total, 94 metabolite profiles of ginseng were studied, including the most volatile secondary metabolites.
The method used in this article could be an essential step in the extraction of information from high-throughput data acquired in the study of systems biology, metabolomics, and biomarker discovery.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Ze-ying& Zeng, Zhong-da& Xiao, Zi-dan& Mok, Daniel Kam-wah& Liang, Yi-zeng& Chau, Foo-tim…[et al.]. 2017. Semiautomated Alignment of High-Throughput Metabolite Profiles with Chemometric Tools. Journal of Analytical Methods in Chemistry،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1170360
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Ze-ying…[et al.]. Semiautomated Alignment of High-Throughput Metabolite Profiles with Chemometric Tools. Journal of Analytical Methods in Chemistry No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1170360
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Ze-ying& Zeng, Zhong-da& Xiao, Zi-dan& Mok, Daniel Kam-wah& Liang, Yi-zeng& Chau, Foo-tim…[et al.]. Semiautomated Alignment of High-Throughput Metabolite Profiles with Chemometric Tools. Journal of Analytical Methods in Chemistry. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1170360
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1170360
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر