![](/images/graphics-bg.png)
The Cooccurrence of Obesity, Osteoporosis, and Sarcopenia in the Ovariectomized Rat: A Study for Modeling Osteosarcopenic Obesity in Rodents
المؤلفون المشاركون
Kim, Jeong-Su
Ezzat-Zadeh, Zahra
Arjmandi, Bahram H.
Chase, P. Bryant
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-01
دولة النشر
مصر
عدد الصفحات
11
الملخص EN
Background.
Obesity, osteoporosis, and sarcopenia may individually occur due to age-related gradual alterations in body composition.
This study investigates the cooccurrence of these age-related diseases in female animals with low levels of ovarian hormone in the absence of complex multifactorial process of chronological aging.
Methods.
Thirty-six 5- and 10-month-old female rats were chosen to model pre- and postmenopausal women, respectively.
Rats were divided into three treatment groups in each age category—sham, ovariectomized (ovx), and ovx + E2 (17β-estradiol, 10 μg/kg)—and were pair-fed.
Volunteer wheel running activity, body composition, bone microstructure, serum C-telopeptides of type I collagen, bone specific alkaline phosphatase, E2, and gastrocnemius and soleus muscles were analyzed.
Results.
The cooccurrence of osteoporosis, sarcopenia, and obesity was observed in the older ovx rats associated with a significant (p<0.05) increased fat mass (30%), bone loss (9.6%), decreased normalized muscle mass-to-body-weight ratio (10.5%), and a significant decrease in physical activity (57%).
The ratio of tibial bone mineral density to combined muscle mass was significantly decreased in both ovx age categories.
Conclusion.
Ovariectomized rat could be used as an experimental model to examine the effect of loss of ovarian hormones, while controlling for energy intake and expenditure, to conduct obesity and body composition translational research in females without the confounding effect of genetic background.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ezzat-Zadeh, Zahra& Kim, Jeong-Su& Chase, P. Bryant& Arjmandi, Bahram H.. 2017. The Cooccurrence of Obesity, Osteoporosis, and Sarcopenia in the Ovariectomized Rat: A Study for Modeling Osteosarcopenic Obesity in Rodents. Journal of Aging Research،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1170390
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ezzat-Zadeh, Zahra…[et al.]. The Cooccurrence of Obesity, Osteoporosis, and Sarcopenia in the Ovariectomized Rat: A Study for Modeling Osteosarcopenic Obesity in Rodents. Journal of Aging Research No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1170390
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ezzat-Zadeh, Zahra& Kim, Jeong-Su& Chase, P. Bryant& Arjmandi, Bahram H.. The Cooccurrence of Obesity, Osteoporosis, and Sarcopenia in the Ovariectomized Rat: A Study for Modeling Osteosarcopenic Obesity in Rodents. Journal of Aging Research. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1170390
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1170390
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)