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Function of Dicer with regard to Energy Homeostasis Regulation, Structural Modification, and Cellular Distribution
المؤلفون المشاركون
Tong, Xiaohui
Yu, Nianjun
Han, Rongchun
Wang, Tongsheng
المصدر
International Journal of Endocrinology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-25
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
As a type III ribonuclease (RNase III) specifically cleaving double-stranded RNA substrates into short fragments, Dicer is indispensable in a range of physi/pathologic processes, e.g., nutrient deprivation, hypoxia, or DNA damage.
Therefore, much interest has been paid to the research of this protein as well as its products like microRNAs (miRNAs).
The close relationship between Dicer levels and fluctuations of nutrient availability suggests that the protein participates in the regulation of systemic energy homeostasis.
Through miRNAs, Dicer regulates the hypothalamic melanocortin-4 system and central autophagy promoting energy expenditure.
Moreover, by influencing canonical energy sensors like adenosine monophosphate-activated protein kinase (AMPK) or mammalian target of rapamycin (mTOR), Dicer favors catabolism in the periphery.
Taken together, Dicer might be targeted in the control of energy dysregulation.
However, factors affecting its RNase activity should be noted.
Firstly, modulation of structural integrity affects its role as a ribonuclease.
Secondly, although previously known as a cytosolic endoribonuclease, evidence suggests Dicer can relocalize into the nucleus where it could also produce small RNAs.
In this review, we probe into involvement of Dicer in energy homeostasis as well as its structural integrity or cellular distribution which affects its ability to produce miRNAs, in the hope of providing novel insights into its mechanism of action for future application.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tong, Xiaohui& Yu, Nianjun& Han, Rongchun& Wang, Tongsheng. 2020. Function of Dicer with regard to Energy Homeostasis Regulation, Structural Modification, and Cellular Distribution. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1170414
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tong, Xiaohui…[et al.]. Function of Dicer with regard to Energy Homeostasis Regulation, Structural Modification, and Cellular Distribution. International Journal of Endocrinology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1170414
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tong, Xiaohui& Yu, Nianjun& Han, Rongchun& Wang, Tongsheng. Function of Dicer with regard to Energy Homeostasis Regulation, Structural Modification, and Cellular Distribution. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1170414
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1170414
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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