Effects of Antimicrobial Photodynamic Therapy and Local Administration of Minocycline on Clinical, Microbiological, and Inflammatory Markers of Periodontal Pockets: A Pilot Study
المؤلفون المشاركون
Yoshie, Hiromasa
Kubota, Takehiko
Morozumi, Toshiya
Komatsu, Yasutaka
Hokari, Takahiro
Yoshino, Toshiaki
Tanaka, Maki
Tanaka, Yoshie
Shimizu, Taro
Nohno, Kaname
المصدر
International Journal of Dentistry
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-05
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
We evaluated the efficacies of antimicrobial photodynamic therapy (aPDT) and minocycline ointment (MO) on clinical and bacteriological markers and the local host inflammatory response.
Materials and Methods.
A total of 30 patients with chronic periodontitis were randomly assigned to two groups.
Selected periodontal pockets (probing depth 5–7 mm with bleeding on probing) were treated with aPDT or MO.
Measurements of clinical parameters and the collection of gingival crevicular fluid (GCF) and subgingival plaque were performed at baseline, and at 1 and 4 weeks after treatment.
Quantification of periodontopathic bacteria in the sulcus and a multiplex bead immunoassay of ten inflammatory cytokines in the GCF were performed.
Results.
Local MO administration exhibited a significant decrease in scores for clinical parameters (P<0.01) and a significant reduction in bacterial counts (P<0.01) and interleukin-1β and interferon-γ levels at 1 and 4 weeks after treatment (P<0.01).
No significant changes were observed in the aPDT group, except in clinical parameters.
Conclusions.
Although our study had some limitations, we found that while local administration of MO may slightly help to improve clinical, microbiological, and crevicular cytokine levels in periodontal pockets, aPDT did not show any effects.
This trial is registered with the UMIN Clinical Trials Registry UMIN000013376.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hokari, Takahiro& Morozumi, Toshiya& Komatsu, Yasutaka& Shimizu, Taro& Yoshino, Toshiaki& Tanaka, Maki…[et al.]. 2018. Effects of Antimicrobial Photodynamic Therapy and Local Administration of Minocycline on Clinical, Microbiological, and Inflammatory Markers of Periodontal Pockets: A Pilot Study. International Journal of Dentistry،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1170419
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hokari, Takahiro…[et al.]. Effects of Antimicrobial Photodynamic Therapy and Local Administration of Minocycline on Clinical, Microbiological, and Inflammatory Markers of Periodontal Pockets: A Pilot Study. International Journal of Dentistry No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1170419
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hokari, Takahiro& Morozumi, Toshiya& Komatsu, Yasutaka& Shimizu, Taro& Yoshino, Toshiaki& Tanaka, Maki…[et al.]. Effects of Antimicrobial Photodynamic Therapy and Local Administration of Minocycline on Clinical, Microbiological, and Inflammatory Markers of Periodontal Pockets: A Pilot Study. International Journal of Dentistry. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1170419
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1170419
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر