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Long-Term Postpartum Outcomes of Insulin Resistance and β-cell Function in Women with Previous Gestational Diabetes Mellitus
المؤلفون المشاركون
Miao, Zhirong
Wu, Honghua
Ren, Liu
Bu, Nan
Jiang, Lili
Zhang, Junqing
Guo, Xiaohui
Yang, Huixia
المصدر
International Journal of Endocrinology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-26
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aims.
The objective of the present study was to explore the long-term postpartum glucose metabolism in women with previous GDM, and study the mechanism of hyperglycemia from gestation to postpartum by investigating the postpartum insulin resistance and insulin secretion.
Methods.
A total of 321 females with previous GDM were followed up once during 1- to 6-years postpartum.
Characteristics during pregnancy, perinatal period, and postpartum were compared between postpartum NGT and hyperglycemic women.
HOMA-IR and HOMA-β were used to assess insulin resistance and insulin secretion levels with different glucose statuses.
Results.
The prevalence of postpartum hyperglycemia had a fluctuant increase from 25.9% at 1 year, to 53.7% at 5 year.
75 g OGTT 2 hPG during pregnancy was an independent predictor of postpartum hyperglycemia with an OR of 2.15 (95% CI 1.245, 3.722) (P=0.006).
After ROC analysis, the best equilibrium between sensitivity (70.3%) and specificity (60.4%) for 2 hPG was 9.03 mmol/L.
HOMA-IR was increased in postpartum normal glucose tolerance (NGT), prediabetes, and T2DM (1.64 vs.
2.14 vs.
4.27, P<0.001), while HOMA-β was decreased (1.19 vs.
1.11 vs.
0.71, P=0.011).
In pairwise comparison, except for HOMA-IR between prediabetes and T2DM, and HOMA-β between NGT and prediabetes, other differences showed significance.
Conclusions.
75 g OGTT 2h PG during pregnancy higher than 9.03 mmol/L is regarded as an independent risk factor of postpartum hyperglycemia.
Insulin resistance with insufficient insulin secretion compensation is still common phenomenon during long-term postpartum.
Women with heavier insulin resistance in the postpartum period are more likely develop prediabetes, while decreased β-cell function contributes more to T2DM development.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Miao, Zhirong& Wu, Honghua& Ren, Liu& Bu, Nan& Jiang, Lili& Yang, Huixia…[et al.]. 2020. Long-Term Postpartum Outcomes of Insulin Resistance and β-cell Function in Women with Previous Gestational Diabetes Mellitus. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1170474
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Miao, Zhirong…[et al.]. Long-Term Postpartum Outcomes of Insulin Resistance and β-cell Function in Women with Previous Gestational Diabetes Mellitus. International Journal of Endocrinology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1170474
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Miao, Zhirong& Wu, Honghua& Ren, Liu& Bu, Nan& Jiang, Lili& Yang, Huixia…[et al.]. Long-Term Postpartum Outcomes of Insulin Resistance and β-cell Function in Women with Previous Gestational Diabetes Mellitus. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1170474
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1170474
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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