Hypocalcemia with Immune Checkpoint Inhibitors: The Disparity among Various Reports
المؤلفون المشاركون
Piranavan, Paramarajan
Nalluru, Swarna Sri
Ning, Ying
Ackula, Haritha
Siddiqui, Ahmad D.
Trivedi, Nitin
المصدر
International Journal of Endocrinology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-06
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Immune-related adverse events affecting parathyroid function are rarely reported with immune checkpoint inhibitors (ICPIs).
Activating calcium-sensing receptor antibodies causing autoimmune hypoparathyroidism with nivolumab was recently reported.
KEYNOTE-189 and CHECKMATE-067 trials reported a 21–29% hypocalcemia event rate, but the etiology of hypocalcemia was not reported.
A chart review was performed to study patients receiving ICPI from 2015 to 2018 at multiple sites affiliated with Saint Vincent Hospital.
The study population was divided into two groups based on the presence or absence of calcium altering conditions or medications.
True hypocalcemia incidence was calculated after correcting calcium for albumin from the initiation of ICPI to their last follow-up.
Group 1 (n = 83) includes patients with no calcium altering conditions or medications.
Group 2 (n = 98) includes patients on calcium supplements (n = 17), vitamin D (n = 44), bisphosphonates (n = 24), >stage IIIB chronic kidney disease (CKD) (n = 5), and bone metastasis (n = 38).
Hypocalcemia events in Group 1 vs.
Group 2 were 8.4% and 19.3%, respectively.
Our entire study demonstrated 26.8% vs.
1.1% of Grade I vs.
II hypocalcemia events.
However, after correcting the calcium for albumin, hypocalcemia incidence was 0.56% (n = 1).
No further workup was done to investigate the etiology as that patient passed away.
Our data suggest that the true hypocalcemia incidence after using albumin-corrected calcium values is very low in patients receiving IPCI, even in the presence of calcium altering factors.
The percentage of patients with hypocalcemia is much higher and similar to the KEYNOTE-189 and CHECKMATE-067 trials when serum calcium values without albumin correction are used.
Thus, the higher reported incidence of hypocalcemia in these trials is likely due to the reporting of serum calcium without albumin correction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nalluru, Swarna Sri& Piranavan, Paramarajan& Ning, Ying& Ackula, Haritha& Siddiqui, Ahmad D.& Trivedi, Nitin. 2020. Hypocalcemia with Immune Checkpoint Inhibitors: The Disparity among Various Reports. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1170475
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nalluru, Swarna Sri…[et al.]. Hypocalcemia with Immune Checkpoint Inhibitors: The Disparity among Various Reports. International Journal of Endocrinology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1170475
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nalluru, Swarna Sri& Piranavan, Paramarajan& Ning, Ying& Ackula, Haritha& Siddiqui, Ahmad D.& Trivedi, Nitin. Hypocalcemia with Immune Checkpoint Inhibitors: The Disparity among Various Reports. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1170475
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1170475
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر