Serum Zinc-α2-Glycoprotein Levels in Patients with or without Coronary Artery Disease in Chinese North Population
المؤلفون المشاركون
Gong, Fengying
Zhu, Hui juan
Pan, Hui
Wang, Lin jie
Zeng, Yong
Liu, Meijuan
Liu, Zeyu
Yang, Hongbo
Yan, Kemin
المصدر
International Journal of Endocrinology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-27
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Coronary artery disease (CAD), the leading cause of morbidity and mortality, has imposed huge health and economic burdens globally.
Zinc-α2-glycoprotein (ZAG) is a novel adipokine.
Increasing evidence suggests the close relationship between serum ZAG levels and various cardiometabolic risk factors.
However, the relationship between serum ZAG levels and CAD is still not fully clarified.
We conducted this study to evaluate serum ZAG levels and its association with cardiovascular risk factors.
A total of 129 patients with CAD, 99 patients with noncoronary artery disease (NCAD), and 121 controls were recruited in this retrospective study.
CAD (coronary artery stenosis ≥50%) or NCAD (coronary artery stenosis <50%) patients who underwent coronary angiography were diagnosed according to the American Heart Association criteria.
Serum ZAG levels were determined via commercial enzyme-linked immunosorbent assay (ELISA) kits.
The results showed that serum ZAG levels in CAD and NCAD groups were significantly decreased when compared with those in the control group.
Multiple stepwise regression analysis revealed that the grouping variable (control, NCAD, and CAD) was an independent determinant of serum ZAG levels (β = −0.328, P<0.001) after controlling other confounding factors.
Further multivariate ordinary logistic regression analysis demonstrated that the risk of grouping at one level higher in subjects with the lowest tertile of ZAG levels was 2.28-fold higher than those with the highest tertile levels (OR = 3.281, 95% CI 1.782–6.038, P<0.001).
The receiver-operating characteristic (ROC) curve analysis showed that serum ZAG could distinguish CAD patients (AUC = 0.706, 95% CI, 0.643–0.770, P<0.05), NCAD patients (AUC = 0.673, 95% CI, 0.602–0.743, P<0.05), and NCAD and CAD patients (AUC = 0.692, 95% CI, 0.633–0.750, P<0.05) from controls.
In conclusion, serum ZAG levels were significantly decreased in NCAD/CAD patients.
The decreased serum ZAG levels were independently associated with the presence of NCAD/CAD.
ZAG might serve as a candidate diagnostic biomarker for NCAD/CAD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Meijuan& Liu, Zeyu& Zhu, Hui juan& Wang, Lin jie& Yang, Hongbo& Yan, Kemin…[et al.]. 2020. Serum Zinc-α2-Glycoprotein Levels in Patients with or without Coronary Artery Disease in Chinese North Population. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1170489
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Meijuan…[et al.]. Serum Zinc-α2-Glycoprotein Levels in Patients with or without Coronary Artery Disease in Chinese North Population. International Journal of Endocrinology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1170489
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Meijuan& Liu, Zeyu& Zhu, Hui juan& Wang, Lin jie& Yang, Hongbo& Yan, Kemin…[et al.]. Serum Zinc-α2-Glycoprotein Levels in Patients with or without Coronary Artery Disease in Chinese North Population. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1170489
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1170489
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر