Serum Levels of Asprosin, a Novel Adipokine, Are Significantly Lowered in Patients with Acromegaly
المؤلفون المشاركون
Zhang, Yuelun
Ke, Xiaoan
Duan, Lian
Gong, Fengying
Deng, Kan
Yao, Yong
Wang, Linjie
Pan, Hui
Zhu, Huijuan
المصدر
International Journal of Endocrinology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-14
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Asprosin is a novel identified adipokine secreted mainly by white adipose tissue, which is elevated in metabolic diseases such as diabetes and obesity.
Acromegaly is a syndrome caused by pituitary growth hormone (GH) cell adenoma with excessive GH secretion.
Serum adipocytokines levels may be involved in abnormal glycolipid metabolism in acromegaly patients.
Objectives.
To investigate serum asprosin levels in acromegaly patients and its correlation with high GH levels and glucolipid metabolic parameters.
Methods.
A retrospective case-control study was conducted and 68 acromegaly patients and 121 controls were included in this study.
Clinical information and laboratory examinations were collected and serum asprosin levels were measured by commercial ELISA kits.
Results.
Serum asprosin levels in acromegaly patients were significantly lower than controls (P<0.001).
Serum asprosin levels in patients with the course of acromegaly ≥5 years (compared with <5 years), high area under curve of growth hormone (GH-AUC) after 75 g oral glucose tolerance test (OGTT) (compared with low GH-AUC patients), and high IGF-1 SDS group (compared with low IGF-1 SDS group) were significantly reduced (all P<0.05).
Serum asprosin levels in acromegaly patients were negatively correlated with the course of acromegaly, IGF-1 SDS, nadir growth hormone value (GH-Nadir), and GH-AUC after OGTT.
Multiple stepwise linear regression indicated that acromegaly was an independent influencing factor of serum asprosin levels.
According to serum asprosin levels tertiles, the risk of acromegaly in the lowest group was 2.67 times higher than the highest group (OR = 3.665, 95% CI 1.677 ∼ 8.007, P=0.001), and the increased risk of the lowest group still existed after adjusting for gender, age, BMI, and TC (Model 2).
Conclusions.
Serum asprosin levels in acromegaly patients are lowered, which may be related to increased blood glucose and reduced body fat mass caused by long-term high GH levels exposure.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ke, Xiaoan& Duan, Lian& Gong, Fengying& Zhang, Yuelun& Deng, Kan& Yao, Yong…[et al.]. 2020. Serum Levels of Asprosin, a Novel Adipokine, Are Significantly Lowered in Patients with Acromegaly. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1170545
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ke, Xiaoan…[et al.]. Serum Levels of Asprosin, a Novel Adipokine, Are Significantly Lowered in Patients with Acromegaly. International Journal of Endocrinology No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1170545
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ke, Xiaoan& Duan, Lian& Gong, Fengying& Zhang, Yuelun& Deng, Kan& Yao, Yong…[et al.]. Serum Levels of Asprosin, a Novel Adipokine, Are Significantly Lowered in Patients with Acromegaly. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1170545
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1170545
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر