![](/images/graphics-bg.png)
Selenium Supplementation May Decrease Thyroid Peroxidase Antibody Titer via Reducing Oxidative Stress in Euthyroid Patients with Autoimmune Thyroiditis
المؤلفون المشاركون
Tian, Xun
Li, Ning
Su, Rui
Dai, Chenyang
Zhang, Ruiguo
المصدر
International Journal of Endocrinology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
Selenium, as an antioxidant, has been implicated in the development of autoimmune thyroiditis (AIT).
Many studies showed selenium supplementation could decrease thyroid autoantibodies in patients with AIT.
However, the underlying mechanisms have not been well determined.
Therefore, we performed a clinical study to investigate the possible mechanism of beneficial effects of selenium treatment on AIT patients.
Methods.
Forty euthyroid patients with AIT were randomized into two groups.
Group I was treated with 200 μg/day selenium supplementation, and group II received a placebo over a 3-month period.
Thyroid stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), antithyroglobulin antibody (TgAb), malondialdehyde (MDA), total antioxidant capacity (TAC), and superoxide dismutase (SOD) were measured before and 3 months after treatments.
Additionally, twenty healthy volunteers also served as a control group for the evaluation of such parameters in basic condition.
Results.
Totally, 32 patients (group I, n = 18; group II, n = 14) completed the clinical study and were incorporated into the statistics.
MDA level was higher and SOD activity and TAC were lower in patients compared to healthy individuals.
After 3 months, TPOAb titer significantly decreased within group I (P<0.001) but did not change within group II (P=0.001).
There were also no statistically significant changes in TSH and TgAb titers within the two groups (all P>0.05).
Additionally, decreased MDA level (from 6.8 ± 1.3 nmol/ml to 4.9 ± 0.7 nmol/ml; P<0.001) and increased TAC (from 10.0 ± 1.9 mmol/l to 12.9 ± 3.1 mmol/l; P=0.003) and SOD activity (from 72.3 ± 10.3 U/ml to 84.3 ± 13.2 U/ml; P=0.007) were simultaneously observed after 3 months’ selenium treatment.
Moreover, there was a negative correlation between TAC and TgAb/TPOAb and a positive correlation between MDA and TgAb/TPOAb in AIT patients.
Conclusions.
Our findings support the hypothesis that selenium treatment could decrease TPOAb titer via enforcing the defense against oxidative stress in euthyroid patients with AIT, which may be a potential underlying mechanism.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tian, Xun& Li, Ning& Su, Rui& Dai, Chenyang& Zhang, Ruiguo. 2020. Selenium Supplementation May Decrease Thyroid Peroxidase Antibody Titer via Reducing Oxidative Stress in Euthyroid Patients with Autoimmune Thyroiditis. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1170607
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tian, Xun…[et al.]. Selenium Supplementation May Decrease Thyroid Peroxidase Antibody Titer via Reducing Oxidative Stress in Euthyroid Patients with Autoimmune Thyroiditis. International Journal of Endocrinology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1170607
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tian, Xun& Li, Ning& Su, Rui& Dai, Chenyang& Zhang, Ruiguo. Selenium Supplementation May Decrease Thyroid Peroxidase Antibody Titer via Reducing Oxidative Stress in Euthyroid Patients with Autoimmune Thyroiditis. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1170607
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1170607
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)