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Lymph Node Metastases of Medullary Thyroid Cancer: Role of Calcitonin in the Washout Fluid of Fine-Needle Aspiration
المؤلفون المشاركون
Marques, Bernardo
Cunha, Nuno
Martins, Raquel G.
Elvas, Ana Rita
Couto, Joana
Santos, Jacinta
Martins, Teresa
Moniz, Ana Paula
Ilhéu, Olga
Valido, Frederico
Rodrigues, Fernando
المصدر
International Journal of Endocrinology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-04
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Introduction.
The diagnostic value of calcitonin (CT) measurement in fine-needle aspirate washout (FNA-CT) for medullary thyroid cancer (MTC) lymph node (LN) metastases remains to be determined.
It may increase the diagnostic sensitivity, but data on this subject is sparse.
Objective.
Our study aimed to evaluate the utility of FNA-CT in the diagnosis of LN metastases of MTC.
Methods.
We retrospectively investigated, in our institutional database, 69 consecutive FNA LN cytology from 42 patients who underwent FNA cytology and CT measurement in needle washout for suspicious LN between 2012 and 2017.
Results.
From the total of 69 FNA, 30 (43.4%) were performed in patients with personal history of MTC.
MTC was detected in 19 FNA cytology (27.5%), and CT was detectable in needle washout in 23 cases (median = 2014 pg/mL; interquartile range = 490–15111 pg/mL).
Based on the combined results of FNA-CT and FNA cytology, LN surgical resection was performed in 33 cases (47.8%).
Histology reported MTC LN metastases in 21 lesions (63.6%).
Regarding the diagnosis of MTC LN metastases, FNA cytology showed sensitivity of 81.8% and specificity of 97.9%, and FNA-CT demonstrated sensitivity of 100% and specificity of 97.9%.
We determined through ROC analysis an optimal FNA-CT cut-off value of 23 pg/mL for the diagnosis of LN metastases (sensitivity 100%; specificity 100%).
Conclusions.
FNA-CT may be a valuable diagnostic tool for detection of MTC LN metastases, along with FNA cytology, and it should be included in the clinical workup of neck adenopathies in patients with MTC or with thyroid nodules.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Marques, Bernardo& Cunha, Nuno& Martins, Raquel G.& Elvas, Ana Rita& Couto, Joana& Santos, Jacinta…[et al.]. 2020. Lymph Node Metastases of Medullary Thyroid Cancer: Role of Calcitonin in the Washout Fluid of Fine-Needle Aspiration. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1170626
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Marques, Bernardo…[et al.]. Lymph Node Metastases of Medullary Thyroid Cancer: Role of Calcitonin in the Washout Fluid of Fine-Needle Aspiration. International Journal of Endocrinology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1170626
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Marques, Bernardo& Cunha, Nuno& Martins, Raquel G.& Elvas, Ana Rita& Couto, Joana& Santos, Jacinta…[et al.]. Lymph Node Metastases of Medullary Thyroid Cancer: Role of Calcitonin in the Washout Fluid of Fine-Needle Aspiration. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1170626
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1170626
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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