Synthesis, Characterization, and Antileishmanial Activity of Certain Quinoline-4-carboxylic Acids
المؤلفون المشاركون
Mukhtar, M. M.
Awadalla Mohamed, Magdi
Abdelwahid, Mazin A. S.
Mohamed, Malik S.
Latif, Sara A.
Elsaman, Tilal
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Leishmaniasis is a fatal neglected parasitic disease caused by protozoa of the genus Leishmania and transmitted to humans by different species of phlebotomine sandflies.
The disease incidence continues to increase due to lack of vaccines and prophylactic drugs.
Drugs commonly used for the treatment are frequently toxic and highly expensive.
The problem of these drugs is further complicated by the development of resistance.
Thus, there is an urgent need to develop new antileishmanial drug candidates.
The aim of this study was to synthesize certain quinoline-4-carboxylic acids, confirm their chemical structures, and evaluate their antileishmanial activity.
Pfitzinger reaction was employed to synthesize fifteen quinoline-4-carboxylic acids (Q1-Q15) by reacting equimolar mixtures of isatin derivatives and appropriate α-methyl ketone.
The products were purified, and their respective chemical structures were deduced using various spectral tools (IR, MS, 1H NMR, and 13C NMR).
Then, they were investigated against L.
donovani promastigote (clinical isolate) in different concentration levels (200 μg/mL to 1.56 μg/mL) against sodium stibogluconate and amphotericin B as positive controls.
The IC50 for each compound was determined and manipulated statistically.
Among these compounds, Q1 (2-methylquinoline-4-carboxylic acid) was found to be the most active in terms of IC50.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abdelwahid, Mazin A. S.& Elsaman, Tilal& Mohamed, Malik S.& Latif, Sara A.& Mukhtar, M. M.& Awadalla Mohamed, Magdi. 2019. Synthesis, Characterization, and Antileishmanial Activity of Certain Quinoline-4-carboxylic Acids. Journal of Chemistry،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1170787
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abdelwahid, Mazin A. S.…[et al.]. Synthesis, Characterization, and Antileishmanial Activity of Certain Quinoline-4-carboxylic Acids. Journal of Chemistry No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1170787
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abdelwahid, Mazin A. S.& Elsaman, Tilal& Mohamed, Malik S.& Latif, Sara A.& Mukhtar, M. M.& Awadalla Mohamed, Magdi. Synthesis, Characterization, and Antileishmanial Activity of Certain Quinoline-4-carboxylic Acids. Journal of Chemistry. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1170787
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1170787
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر