Changes in the Responsiveness of the Hypothalamic-Pituitary-Gonadal Axis to Kisspeptin-10 Administration during Pubertal Transition in Boys

المؤلفون المشاركون

Shahab, Muhammad
Khan, Suliman
Nabi, Ghulam
Ullah, Hamid
Wahab, Fazal
Duan, Pengfei
Ullah, Rahim
Yao, Lunguang

المصدر

International Journal of Endocrinology

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-06-26

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الأحياء

الملخص EN

In human, no studies are available regarding changes in kisspeptin1 receptor (KISS1R) sensitivity during pubertal transition.

In this study, healthy boys were classified into 5 Tanner stages of puberty (n=5/stage).

Human kisspeptin-10 was administered to boys at each Tanner stage and to adult men (n=5) as an IV bolus for comparison.

Serial blood samples were collected for 30 min pre- and 120 min post-kisspeptin injection periods at 30 min interval for measuring plasma LH and testosterone levels.

There was insignificant effect of kisspeptin on LH and testosterone levels in boys of Tanner stages I–III.

At Tanner stage IV, the effect of kisspeptin on plasma LH was insignificant.

However, a paired t-test on a log-transformed data showed a significant (P<0.05) increase in mean peak post-kisspeptin testosterone level.

In Tanner stage V, a significant (P<0.05) increase was observed in mean post-kisspeptin peak LH level as compared to the mean basal LH value.

Post-kisspeptin plasma testosterone levels were also significantly (P<0.05) increased as compared to the pre-kisspeptin level in Tanner stage V.

Our data suggest that sensitivity of KISS1R on GnRH neurons with reference to LH stimulation in boys develops during the later part of puberty reaching to adult level at Tanner stage V.

This trial is registered with WHO International Clinical Trial Registration ID NCT03286517.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Nabi, Ghulam& Ullah, Hamid& Khan, Suliman& Wahab, Fazal& Duan, Pengfei& Ullah, Rahim…[et al.]. 2018. Changes in the Responsiveness of the Hypothalamic-Pituitary-Gonadal Axis to Kisspeptin-10 Administration during Pubertal Transition in Boys. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1171018

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Nabi, Ghulam…[et al.]. Changes in the Responsiveness of the Hypothalamic-Pituitary-Gonadal Axis to Kisspeptin-10 Administration during Pubertal Transition in Boys. International Journal of Endocrinology No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1171018

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Nabi, Ghulam& Ullah, Hamid& Khan, Suliman& Wahab, Fazal& Duan, Pengfei& Ullah, Rahim…[et al.]. Changes in the Responsiveness of the Hypothalamic-Pituitary-Gonadal Axis to Kisspeptin-10 Administration during Pubertal Transition in Boys. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1171018

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1171018